The Thrombolytic Effect of Heparin and a Heparin-Like Substance, SP 54

Summary

The intravenous administration of heparin or SP 54 produced statistically significant reductions in the weights of experimentally induced jugular thrombi, which had been allowed to grow for 48, 72, or 120 hrs before treatment. The results observed in the smaller saphenous veins were less striking.

^* Current address: Department of Medicine, Guy’s Hospital Medical School, London Bridge, S. E. London.

• References

• 1 Carey L. G, Williams R. D. Comparative effects of dicoumarol, tromexan and heparin on thrombus propagation. Ann. Surg 152: 919-922 1960;
• 2 Coons A. H, Kaplan M. H. Localization of antigen in tissue cells: II. Improvements in a method for the detection of antigen by means of fluorescent antibody. J. exp. Med 91: 1 1950;
• 3 Fegan W. G, FitzGerald D. E. The treatment of venous insufficiency in pregnancy. J. Obstet. Gynaec. Cwlth 73: 122-125 1966;
• 4 Goddan M. A, Edwards M. R, Tompkins V. N. Refinement of Fluorescent Antibody by Gel Filtration. Proc. Soc. exp. Biol. (N. Y.) 109: 96 1962;
• 5 Halse Th. Polyelectrolytes as activators of fibrinolysis and thrombolysis. Sangre (Barcelona) od. (Santiago) 9: 149-152 1964;
• 6 Lewis J. H, Kerber C. W, Wilson J. H. Effects of fibrinolytic agents and heparin in intravascular clot lysis. Amer. J. Physiol 207: 1044-1048 1964;
• 7 Lewis J. H, Szeto I. L. F, Bayer W. L, Takaori M, Safar P. Severe Hemodilution with Hydroxyethyl Starch and Dextrans. Arch. Surg 93: 941-950 1966;
• 8 Morris L. E, Balk Ph. The management and mismanagement of acute venous thrombosis of the extremities. Angiology 16: 339-345 1965;
• 9 Olesen E. S. A fibrinolytic system in human plasma activated by peptone or acid polysaccharides. Scand. J. clin. Lab. Invest 13: 410-415 1961;
• 10 Sandritter W. G, Schlüter G. Koppel Experimental thrombolysis in animal experiments with SP 54 and streptokinase. Med. Welt 1964; 2732-2739.
• 11 Williams R. D, Karaffa F. Comparison of fibrinolysin and heparin on induced venous thrombosis and thrombolysis. Surg. Gynec. Obstet 121: 309-312 1965;
• 12 Zweifler A. J. Standardized technique for the study of thrombus growth: effect of heparin therapy. J. Lab. clin. Med 60: 254-260 1962;