Amino Acid Transport into Human Platelets and Subsequent Incorporation into Protein

I. A Cooper; B. G Firkin

doi:10.1055/s-0038-1654128

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1970; 23(01): 140-147
DOI: 10.1055/s-0038-1654128

Originalarbeiten – Original Articles – Travaux Originaux

Schattauer GmbH

Amino Acid Transport into Human Platelets and Subsequent Incorporation into Protein

Authors

I. A Cooper¹⁾²⁾⁵⁾⁷⁾

¹Clinical Research Unit, Royal Prince Alfred Hospital, and Department of Medicine, University of Sydney, Sydney, Australia
B. G Firkin³⁾⁴⁾⁶⁾

¹Clinical Research Unit, Royal Prince Alfred Hospital, and Department of Medicine, University of Sydney, Sydney, Australia

Abstract

Summary

Human platelets are known to contain various protein components. Among them are fibrinogen and other soluble proteins. The origin of such proteins has not been clear.

Studies were designed to demonstrate the ability of the platelet to incorporate amino acids and subsequently utilise these for de novo protein synthesis.

Seven different ¹⁴C labelled amino acids were used, cysteine, lysine, serine, glutamic acid, proline, valine und leucine.

Active incorporation into platelets of all these amino acids was demonstrated with some evidence for incorporation of cysteine, lysine and serine into the fibrinogen and soluble protein.

Full Text

References

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