Thromb Haemost 1995; 73(03): 435-438
DOI: 10.1055/s-0038-1653793
Original Articles
Coagulation
Schattauer GmbH Stuttgart

Factor VII Coagulant Activity in Relation to Serum Lipoproteins and Dietary Fat in Middle-aged Men

Sari Väisänen
1   The Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
,
Tuomo Rankinen
1   The Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
,
IIkka Penttilä
2   Department of Clinical Chemistry, Kuopio University, Kuopio, Finland
,
Rainer Rauramaa
1   The Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
› Author Affiliations
Further Information

Publication History

Received08 September 1994

Accepted after revision 30 November 1994

Publication Date:
09 July 2018 (online)

Summary

The associations of serum lipoproteins and habitual diet to factor VII coagulant activity (FVIIc) were analysed in 119 middle-aged men. FVIIc was measured by one-stage clotting assay, cholesterol and triglycerides enzymatically, serum apolipoproteins (apo) immunoturbi- dimetrically and habitual diet using four-day food records. ApoB, cholesterol, triglycerides, apoA-II, LDL cholesterol and dietary fat correlated directly to FVIIc (p <0.001). In multivariate analysis apoB, dietary fat and apoA-II explained 35.3% of the variance in FVIIc. In the lowest apoB tertile FVIIc was increased only when fat intake was high (>38 E%), in the middle tertile FVIIc increased gradually from low to high fat intake, whereas in the highest apoB tertile FVIIc was not related to dietary fat (p = 0.038 for age-adjusted interaction). The present data demonstrate a direct relation between apoB and FVIIc in middle-aged men. Low fat diet seem to associate to decreased FVIIc especially in subjects in the lower end of the apoB distribution.

 
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