Thromb Haemost 1971; 26(03): 467-473
DOI: 10.1055/s-0038-1653699
Originalarbeiten – Original Articles – Travaux Originaux
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Effects of a Variety of Endotoxins on Human and Rabbit Platelet Function

M Nagayama*
1   Departments of Obstetrics and Gynecology and Pathology, New York University School of Medicine
,
M. B Zucker**
1   Departments of Obstetrics and Gynecology and Pathology, New York University School of Medicine
,
F. K Beller***
1   Departments of Obstetrics and Gynecology and Pathology, New York University School of Medicine
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Publikationsdatum:
24. Juli 2018 (online)

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Summary

Endotoxin from Salmonella typhosa or enteritidis, Escherichia coli, or Serratia marcescens caused platelet aggregation, release of platelet-bound 14C-serotonin and development of platelet factor 3 activity when shaken at 37 °C with heparinized platelet-rich plasma (10 units/ml) from rabbits. The relative activity in each test differed for each agent. Endotoxoid only released 14C-serotonin. With human platelet-rich plasma, Salmonella typhosa, E. coli or Serratia marcescens endotoxin failed to induce aggregation or platelet factor 3 activity but caused slow release of platelet-bound 14C-serotonin. Earlier studies showed that endotoxemia in man or endotoxoid injection in rabbits was associated with thrombocytopenia without shock or disseminated intravascular coagulation. This effect appears to correlate with release of 14C-serotonin from platelets in vitro.

* N. I. H. Trainee in Reproductive Physiology (Grant HD 002 70-05).


** This work was partially supported by grant HE-12859 from the National Institutes of Health.


*** Career Investigator of the Health Research Council of the City of New York (1-296).