Thromb Haemost 1969; 21(01): 524-533
DOI: 10.1055/s-0038-1653566
Originalarbeiten - Original Articles - Travaux Originaux
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The Influence of the Polysaccharide Carrageenin on the Clotting Mechanism of the Blood in the Rabbit in Vitro and in Vivo[*]

K L Schimpf
1  University of Heidelberg, Medical Department (Ludolf -Krehl-Klinik)
,
J Lenhard
1  University of Heidelberg, Medical Department (Ludolf -Krehl-Klinik)
,
G Schaaf
1  University of Heidelberg, Medical Department (Ludolf -Krehl-Klinik)
› Author Affiliations
Further Information

Publication History

Publication Date:
10 June 2018 (online)

Summary

Carrageenin is not an antithrombin. It inhibits fibrin aggregation or polymerisation. The inactivation of thrombin by antithrombin and of blood thromboplastin by anti blood thromboplastin is neither accelerated nor retarded. In the presence of Carrageenin the clotting times of tests in which the fibrinpolymerisation phase is involved are lengthened; this simulates a decrease in clotting factors. In vivo Carrageenin, despite its coagulation-inhibitory properties, is not able to reverse the consumption reaction which it has initiated.

* With the aid of a grant from the Deutsche Forschungsgemeinschaft.