Thromb Haemost 1969; 21(01): 403-408
DOI: 10.1055/s-0038-1653554
Originalarbeiten - Original Articles - Travaux Originaux
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The Effect of Urea on Aggregation and Incubation Resistance of Human Platelets[*]

H Reuter
1  Medical Clinic of the University of Cologne (Head: Prof. Dr. R. Gross)
,
H Linker
1  Medical Clinic of the University of Cologne (Head: Prof. Dr. R. Gross)
› Author Affiliations
Further Information

Publication History

Publication Date:
10 June 2018 (online)

Summary

Investigations have been carried out to study the effect of urea on aggregation and incubation resistance of human platelets. Urea in high concentrations inhibits the Ca++-induced aggregation in platelet-rich EDTA-plasma while at low concentrations an increased aggregation takes place. Incubation of platelet-rich plasma at 37° C in the absence of divalent cations was performed in the presence and absence of 0.1 M urea. The temperature-induced percentage inhibition of aggregation was found to be significantly lower in the presence of urea.

* This work was supported by the Deutsche Forschungsgemeinschaft.