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Thromb Haemost 1969; 21(02): 373-379
DOI: 10.1055/s-0038-1653548
Originalarbeiten - Original Articles - Travaux Originaux
Schattauer GmbH

The Effect of Adenosine Phosphates on the Spreading of Normal Human Platelets

H Linker
1   Medical Clinic of the University of Cologne (Head: Prof. Dr. E. Gross)
,
H Reuter
1   Medical Clinic of the University of Cologne (Head: Prof. Dr. E. Gross)
› Institutsangaben
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Publikationsdatum:
10. Juni 2018 (online)

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Summary

The spreading of human platelets requires the presence of ADP as do other platelet functions. In the plasma of patients with a failure of release of ADP from the platelets the also decreased ability to spread can be normalized by exogenous ADP. AMP and ATP inhibit the spreading of platelets.

 

  • References

  • 1 Bloom A. L, Davies A. J. Adenosine Diphosphate and the Measurement of Platelet Adhesiveness. J. clin. Path 20: 706 1967;
    CrossrefPubMedGoogle Scholar
  • 2 Born G. V. R. The breakdown of adenosine triphosphate in blood platelets during clotting. J. Physiol. (Lond.) 133: 61P-62P 1956;
    PubMedGoogle Scholar
  • 3 Born G. V. R. Adenosinetriphosphate in Blood Platelets. Biochem. J 62: 33 1956;
    PubMedGoogle Scholar
  • 4 Born G. V. R. Uptake of adenosine and of adenosine diphosphate by human blood platelets. Nature (Lond.) 206: 1121-1122 1965;
    CrossrefPubMedGoogle Scholar
  • 5 Born G. V. R. Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal. Nature (Lond.) 194: 927-929 1962;
    PubMedGoogle Scholar
  • 6 Born G. V. R. Strong inhibition by 2-chloradenosine of the aggregation of blood platelets by adenosine diphosphate. Nature (Lond.) 202: 95 1964;
    PubMedGoogle Scholar
  • 7 Born G. V. R, Gross M. J. Inhibition of the aggregation of blood platelets by substances related to adenosine diphosphate. J. Physiol. (Lond.) 166: 29P-30P 1983;
    PubMedGoogle Scholar
  • 8 Born G. V. R, Cross M. J. The aggregation of blood platelets. J. Physiol. (Lond.) 168: 178-195 1963;
    CrossrefPubMedGoogle Scholar
  • 9 Born G. V. R, Cross M. J. Effect of adenosine diphosphate on the concentration of platelets in circulating blood. Nature (Lond.) 197: 974 1963;
    CrossrefPubMedGoogle Scholar
  • 10 Born G. V. R, Haslam R. J, Goldman M, Lowe R. D. Comparative effectiveness of adenosine analogues as inhibitors of blood-platelets aggregation and as vasodilators in man. Nature (Lond.) 205: 678 1965;
    CrossrefPubMedGoogle Scholar
  • 11 Braunsteiner H. Thrombopathie und Thrombasthenie. Beih. zu Wien. Z. inn. Med 36 1955;
    PubMedGoogle Scholar
  • 12 Braunsteiner H, Fellinger K, Pakesch F. Elektronenmikroskopische Beobachtungen der Blutplättchen bei Thrombasthenie. Klin. Wschr 31: 21 1953;
    CrossrefPubMedGoogle Scholar
  • 13 Breddin K. Zur Messung der Thrombozytenadhäsivität. Thrombos. Diathes. haemorrh. (Stuttg.) 12: 269 1964;
    PubMedGoogle Scholar
  • 13a Breddin K, Bruch K. H. Zur Klinik der Thrombozytenfunktionsstörungen unter besonderer Berücksichtigung der Ausbreitungsfähigkeit der Thrombozyten an silikonisierten Glasflächen. Thrombos. Diathes. haemorrh. (Stuttg.) 09: 525-545 1963;
    PubMedGoogle Scholar
  • 13b Breddin K, Langbein H. Über den Einfluß verschiedener Stoffwechselhemmer auf die Thrombozytenfunktion. Thrombos. Diathes. haemorrh. (Stuttg.) 10: 29-41 1963;
    PubMedGoogle Scholar
  • 14 Clayton S, Born G. V. R, Cross M. J. Inhibition of the aggregation of blood platelets by nucleosides. Nature (Lond.) 200: 138-139 1963;
    CrossrefPubMedGoogle Scholar
  • 15 Constantine J. W. Temperature and the Aggregation of Rabbit Platelets by Adenosine Diphosphate. Nature (Lond.) 205: 1075-1077 1965;
    CrossrefPubMedGoogle Scholar
  • 16 Constantine J. W. Aggregation and Adhesion of Rat Platelets. Nature (Lond.).. 214. 1084 bis 1086 1967
    PubMedGoogle Scholar
  • 17 Gaarder A, Laland S. Hypothesis for the Aggregation of Platelets by Nucleotides. Nature (Lond.) 202: 909-910 1964;
    CrossrefPubMedGoogle Scholar
  • 18 Gaarder A, Jonsen J, Laland S, Hellem A, Owren P. A. Adenosine Diphosphate in Red Cells as a Factor in the Adhesiveness of Human Blood Platelets. Nature (Lond.) 192: 531-532 1961;
    CrossrefPubMedGoogle Scholar
  • 19 Gross R. Aktuelle Probleme des Thrombozytenersatzes. Ber. 7. Tag. Dtsch. Ges. Bluttransf., Berlin 1958, Bibi, haemat. (Basel.) 09: 92 1959;
    PubMedGoogle Scholar
  • 20 Gross R. Pathophysiologie und Klinik der Thrombozytopa4/26/2017 10:20AMthien. Yerh. dtsch. Ges. inn. Med. 66. Kongr 814 1960;
    PubMedGoogle Scholar
  • 21 Gross R, Gerok W, Löhr G. W, Vogel W, Waller H. D, Theopold W. Über die Natur der Thrombasthenie Thrombopathie Glanzmann-Naegeli. Klin. Wschr 38: 193 1960;
    CrossrefPubMedGoogle Scholar
  • 22 Gross R, Löhr G. W, Waller H. D. Long term preservation of functionally intact platelets. Proc. 7th Congr. europ. soc. haemat. London 1959 Part II 686 1960
    PubMedGoogle Scholar
  • 23 Gross R, Niemeyer G, Reuter H. Ein methodischer Beitrag zur Funktionsprüfung menschlicher Blutplättchen unter standardisierten Bedingungen. Dtsch. med. Wschr. (Im Druck.)
    PubMedGoogle Scholar
  • 24 Gross R, Kahlstorf J, Nies D. Platelet aggregation from functional and biochemical points of view. X th Congress of the international society of Haematology.
    PubMedGoogle Scholar
  • 25 Hampton J. R, Mitchell J. R. A. An estimate of the Number of Adenosine Diphosphate Binding sites on Human Platelets. Nature (Lond.) 211: 245-246 1966;
    CrossrefPubMedGoogle Scholar
  • 26 Hovig T, Holmsen H. Release of a platelet-aggregating substance (adenosine diphosphate. from rabbit blood platelets induced by saline “extract” of tendons. Thrombos. Diathes. haemorrh. (Stuttg.) 09: 264-278 1963;
    PubMedGoogle Scholar
  • 27 Hürter H. Ein methodischer Beitrag zur Ausbreitungsfähigkeit menschlicher Blutplättchen an silikonisierten Oberflächen. Inaug. Diss. Köln. (In Vorbereitung.)
    PubMedGoogle Scholar
  • 28 Kröhl R, Wenzel E, Breddin K. Stoffwechselhemmung und Thrombozytenfunktion. Verh. dtsch. Ges. inn. Med 73: 399 1967;
    PubMedGoogle Scholar
  • 29 Löhr G. W. Differentialdiagnose und Pathogenese der hereditären Thrombopathien. Med. Welt 771 1961;
    PubMedGoogle Scholar
  • 30 Löhr G. W, Waller H. D. Zellstoffwechsel und Zellalterung. Klin. Wschr 37: 833 1959;
    CrossrefPubMedGoogle Scholar
  • 31 Macmillan D. G. Secondary clumping effect in human citrated platelet-rich plasma produced by adenosine diphosphate and adrenaline. Nature (Lond.) 211: 140-144 1966;
    CrossrefPubMedGoogle Scholar
  • 32 Macmillan D. G, Oliver M. F. The initial changes in platelet morphology following the addition of adenosine diphosphate. J. atheroscler. Res 05: 440-444 1965;
    CrossrefPubMedGoogle Scholar
  • 33 Marcus A. J, Zucker M. B. The Physiology of Blood Platelets. Grune and Stratton, Inc; New York, London: 1965
    Google Scholar
  • 34 Mitchell J. R. A, Sharjp A. A. Platelet Clumping in vitro. Brit. J. Haemat 10: 78-93 1964;
    CrossrefPubMedGoogle Scholar
  • 35 Mustard J. F, Hegardt B, Rosseil H. G, MacMillan R. L. Effect of adenosine nucleotides on platelet aggregation and clotting time J. Lab. clin. Med 64: 548 1964;
    PubMedGoogle Scholar
  • 36 Niemeyer G, Reuter H. Zur Zählung und Funktionsprüfung der Blutplättchen. Internist 09: 48-55 1968;
    PubMedGoogle Scholar
  • 37 Niemeyer G, Reuter H, Gross R. Unveröffentlicht.
    PubMedGoogle Scholar
  • 38 O’Brien J. R. Some effects of the adenosine phosphates, thrombin and cocaine upon platelet adhesiveness. J. clin. Path 15: 446-455 1962;
    CrossrefPubMedGoogle Scholar
  • 39 O’Brien J. R. A comparison of platelet aggregation produced by seven compounds and a comparison of their inhibitors. J. clin. Path 17: 275-281 1964;
    CrossrefPubMedGoogle Scholar
  • 40 O’Brien J. R. Platelet stickiness. Ann. Rev. Med 17: 275 1966;
    CrossrefPubMedGoogle Scholar
  • 40a O’Brien J. R. Platelets: A Portsmouth Syndrome. Lancet 1967; 285.
    PubMedGoogle Scholar
  • 41 Reuter H, Linker H. The Effect of Urea on Aggregation and Incubation Resistance of human Platelets. (In Vorbereitung.)
    PubMedGoogle Scholar
  • 42 Reuter H, Niemeyer G, Gross R. Zur Differenzierung der Plättchenaggregation. Intern. Sympos. über Stoffwechsel u. Membranpermeabilität von Erythrozyten und Thrombozyten. Wien 1968. Thieme, Stuttgart (Im Druck).
    PubMedGoogle Scholar
  • 43 Sinakos Z, Gaen J. Agrégabilité des plaquettes de diverses espèces animales (Etude microscopique et photometrique). Nouv. Rev. franç. Hémat 07: 120 1967;
    PubMedGoogle Scholar
  • 44 Waller H. D, Gross R. Genetische Enzymdefekte als Ursache von Thrombopathien. Verh. dtsch. Ges. inn. Med. 70 Kongr. S 475 1964;
    PubMedGoogle Scholar
  • 45 Waller H. D, Löhr G. W, Grignani F, Gross R. Über den Energiestoffwechsel normaler menschl. Thrombozyten. Thrombos. Diathes. haemorrh. (Stuttg.) 03: 520 1959;
    PubMedGoogle Scholar
  • 46 Zucker M. B, Zaccardi J. B. Coagulation I. Platelet shape change induced by adenosine diphosphate and prevented by adenosine monophosphate. Fed. Proc 23: 299 1964;
    PubMedGoogle Scholar