Thromb Haemost 1969; 21(01): 367-372
DOI: 10.1055/s-0038-1653547
Originalarbeiten - Original Articles - Travaux Originaux
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A Simple Technique for the Experimental Production of Acute Platelet Deficiency

R.C Dutton*
1  Laboratory of Technical Development, Biomedical Engineering and Instrumentation Branch, and Clinical Pathology Department, National Institutes of Health, Bethesda, Maryland
,
R.L Dedrick
1  Laboratory of Technical Development, Biomedical Engineering and Instrumentation Branch, and Clinical Pathology Department, National Institutes of Health, Bethesda, Maryland
,
B.S Bulli**
1  Laboratory of Technical Development, Biomedical Engineering and Instrumentation Branch, and Clinical Pathology Department, National Institutes of Health, Bethesda, Maryland
› Author Affiliations
Further Information

Publication History

Publication Date:
10 June 2018 (online)

Summary

This report describes a new simple technique for producing acute controlled thrombocytopenia by allowing platelets to adhere to activated carbon granules or glass beads during hemoperfusion of an experimental animal. The level of platelet deficiency produced may be regulated by terminating perfusion when the desired level is reached. Perfusion on consecutive days removes the newly released platelets and restores the thrombocytopenic state.

* Present address: University of California Medical School, San Francisco, California.


** Present address: Department of Pathology, Loma Linda University School of Medicine, Loma Linda, California.