Relationship between Electrical and Spontaneous Thrombosis[*]Coagulation Inhibition of Intrinsic System
10 June 2018 (online)
The triggering of electrical thrombosis on electrodes depends on the coagulation steps prior to factor IX activation. Factor XII may be responsible for this phenomenon. The platelet may also play a role. It has been shown that platelet deposition is visible at potentials more positive than +0.3 V versus the normal hydrogen electrode. The same compounds which inhibit intravascular thrombosis will also impair electrical thrombosis.
* Supported in part by grants No. HE 07371, 07821 and 10795 from the National Heart Institute, National Institutes of Health, United States Public Servies, Bethesda, Maryland.
1 Department of Experimental Medicine, University College, Galway, Ireland.
- 1 Sawyer P. N, Pate J. W. Bioelectric phenomena as etiologic factors in intravascnlar thrombosis. Surg 34: 491 1953;
- 2 Sawyer P. N, Srinivasan S. Studies on the biophysics of intravascular thrombosis. Amer. J. Surg 114 4: 3 1967;
- 3 Lavelle S. M, Brown J. G, Srinivasan S, Sawyer P. N. Observations on the role of interfacial potentials on thrombus deposition at conducting surfaces. (To be published).
- 4 Chopra P. S, Srinivasan S, Lucas T, Sawyer P. N. Relation between thrombosis on metal electrodes and the position of metal in the electromotive series. Nature (Lond) 215: 1494 1967;
- 5 Ratnoff O. D, Rosenblum J. M. Role of Hageman Factor in the Initiation of Clotting by Glass. Amer. J. Med 25: 160 1958;
- 6 Lavelle S. M. Unpublished..
- 7 Langdeil R. D, Wagner R. H, Brinkhous K. M. Effect of antihemophiliac factor on one- stage clotting tests. J. Lab. clin. Med 41: 637-647 1953;
- 8 Langdell R. D, Wagner R. H, Brinkhous K. M. Antihemophiliac factor (AHF) levels following transfusions of blood, plasma and plasma fractions.
- 9 Zivkovic R, Kasper T. G, Srinivasan S, Sawyer P. N. Biochemical studies on the mechanism of thrombosis : dependence of release of adenine nucleotides from platelets exposed to some metals. (To be published).
- 10 Sawyer P. N, Reardon J. H, Ogoniak J. G. Irreversible electrochemical precipitation of mammalian platelets and intravascular thrombosis. Proc. nat. Acad. Sei 53: 200 1965;