Thromb Haemost 1969; 21(01): 325-331
DOI: 10.1055/s-0038-1653542
Originalarbeiten - Original Articles - Travaux Originaux
Schattauer GmbH

Relationship between Electrical and Spontaneous Thrombosis[*]

Coagulation Inhibition of Intrinsic System
J.C Brown M.D.
1  The Electrochemical and Biophysical Laboratories of the Vascular Surgical Services, Departments of Surgery and Surgical Research, State University of New York, Down- state Medical Center, Brooklyn, New York 11203
,
S.M Lavelle M.D.*
1  The Electrochemical and Biophysical Laboratories of the Vascular Surgical Services, Departments of Surgery and Surgical Research, State University of New York, Down- state Medical Center, Brooklyn, New York 11203
,
P.N Sawyer M.D.
1  The Electrochemical and Biophysical Laboratories of the Vascular Surgical Services, Departments of Surgery and Surgical Research, State University of New York, Down- state Medical Center, Brooklyn, New York 11203
› Author Affiliations
Further Information

Publication History

Publication Date:
10 June 2018 (online)

Summary

The triggering of electrical thrombosis on electrodes depends on the coagulation steps prior to factor IX activation. Factor XII may be responsible for this phenomenon. The platelet may also play a role. It has been shown that platelet deposition is visible at potentials more positive than +0.3 V versus the normal hydrogen electrode. The same compounds which inhibit intravascular thrombosis will also impair electrical thrombosis.

* Supported in part by grants No. HE 07371, 07821 and 10795 from the National Heart Institute, National Institutes of Health, United States Public Servies, Bethesda, Maryland.


1 Department of Experimental Medicine, University College, Galway, Ireland.