Thromb Haemost 1969; 21(02): 294-303
DOI: 10.1055/s-0038-1653538
Originalarbeiten - Original Articles - Travaux Originaux
Schattauer GmbH

Fibrinolytic Activity of Cerebro-Spinal Fluid and the Development of Artificial Cerebral Haematomas in Dogs

H Mihara1)
1  Kobe University School of Medicine, Japan
T Fujii2)
1  Kobe University School of Medicine, Japan
S Okamoto3)
1  Kobe University School of Medicine, Japan
› Author Affiliations
Further Information

Publication History

Publication Date:
10 June 2018 (online)


Blood was injected into the brains of dogs to produce artificial haematomas, and paraffin injected to produce intracerebral paraffin masses. Cerebrospinal fluid (CSF) and peripheral blood samples were withdrawn at regular intervals and their fibrinolytic activities estimated by the fibrin plate method. Trans-form aminomethylcyclohexane-carboxylic acid (t-AMCHA) was administered to some individuals. Genera] relationships were found between changes in CSF fibrinolytic activity, area of tissue damage and survival time. t-AMCHA was clearly beneficial to those animals given a programme of administration. Tissue activator was extracted from the brain tissue after death or sacrifice for haematoma examination. The possible role of tissue activator in relation to haematoma development, and clinical implications of the results, are discussed.

1) Assistant Professor, Department of Physiology.

2) Research Fellow, Department of Surgery.

3) Professor of Physiology, Kobe University.