A Study of Possible Causes of Increased Fibrinolytic Activity during Exercise

Summary

The prolonged effect in human volunteers of brief but moderately intense exercise in enhancing fibrinolytic activity has been used to test various parameters which might have been causatively associated with the change.

HMMA, venous blood glucose, body temperature and diastolic blood pressure did not alter significantly at any time. The increase in pulse rate immediately after exercise did not correlate closely with the rise in fibrinolytic activity and disappeared much sooner.

Plasma cortisol and systolic blood pressure had both fallen significantly 1 hr after exercise as compared to their preexercise levels, but there was no significant inverse relationship between these parameters and the changes in fibrinolytic activity.

It is concluded that the parameters measured were unlikely to be responsible for the observed changes in fibrinolytic activity.

• References

• Bedrak E. Effect of muscular exercise in a hot environment on canine fibrinolytic activity. J. appl. Physiol 20: 1307 1965;
• Biggs R, Farlane R. GMac, Pilling J. Observation on fibrinolysis. Experimental activity produced by exercise or adrenaline. Lancet I: 402 1947;
• Billimoria J. D, Drysdale J, James D. C. O, Lagan N. FMac. Determination of fibrinolytic activity of whole blood (with special reference to the effects of exercise and fat feeding). Lancet 11: 471 1959;
• Burt J. J, Blyth G. S, Rierson H. A. The effects of exercise on the coagulation fibrinolysis equilibrium. J. Sport Med. (Torino) 04: 213 1964;
• Carlsson C, Dencker S. J, Grimby G, Haggendal J. Noradrenaline in human blood plasma and urine during exercise in patients receiving large doses of chlorpromazine. Acta pharmacol. (Kbh) 25: 97 1967;
• Gash J. D. Effect of moderate exercise on the fibrinolytic system in normal young men and women. Brit. med. J II: 502 1966;
• Gornil A, de Coster A, Gopinschi G, Franckson J. R. M. Effect of muscular exercise on the plasma level of cortisol in man. Acta endocr. (Kbh) 48: 163 1965;
• Fearnley G. R, Lackner R. The fibrinolytic activity of normal blood. Brit. J. Haemat 01: 189 1955;
• Genton E, Kern Jr. F, von Kaulla K. N. Fibrinolysis induced by pressure amines. Amer. J. Med 31: 564 1961;
• Holemans R. Origin of blood fibrinolytic activity. Lancet II: 365 1963;
• Jang E, Fletcher B. T, Bickford A. F. Effect of exercise on the time of clot lysis in normal subjects and patients with cirrhosis of the liver. Clin. Sci 27: 9 1964;
• Kwaan H. C, McFadzean A. J. S, Cook J. Plasma fibrinolytic activity in cirrhosis of the liver. Lancet I: 132 1956;
• Master A. M. The two-step test of myocardial function. Amer. Heart J 10: 495 1935;
• Menon I. S. Exercise and blood fibrinolysis. Lancet. II. 1365 1966a
• Menon I. S. Exercise and fibrinolysis. Brit. med. J.. II. 829 1966b
• Menon I. S. Fibrinolytic activity in the blood of Nigerian students after four years residence in the U. K. Lab. Pract 16: 574 1967;
• Menon I. S, Burke F. D, Dewar H. A. The effect of strenuous and graded exercise on fibrinolytic activity. Lancet. I. 700 1967a
• Menon I. S, Smith P. A, White R. W. B, Dewar H. A. Diurnal variations of fibrinolytic activity and plasma 11-hydroxycorticosteroid levels. Lancet. II. 531 1967b
• Ogston D, Fullerton H. W. Changes in fibrinolytic activity produced by physical activity. Lancet 11: 730 1961;
• Ogston D, McAndrew G. M. Fibrinolysis in obesity. Lancet II: 1205 1964;
• Sherry S, Lindemeyer R. I, Fletcher A. P, Alkjaersig N. Studies on enhanced fibrinolytic activity in man. J. clin. Invest 38: 810 1959;
• Suzuki T, Otsuka K, Matsui H, Ohukuzi S, Sakai K, Harada Y. Effect of muscular exercise on adrenal 17-hydroxycorticosteroid secretion in the dog. Endocrinology 80: 1148 1967;
• Truelove S. C. Fibrinolysis and the eosinophil count. Clin. Sci 10: 229 1951;
• von Kaulla K. N. Chemistry of Thrombolysis. Human Fibrinolytic Enzymes. 79 Thomas, Springfield, Ill: 1963