Congenital Factor VII Deficiency Two Cases in Children of Cousins
10 June 2018 (online)
Two siblings with factor VII deficiency are described, whose parents are cousins. The factor VII levels of the parents and 32 other family members were determined. The parents and 17 other relatives were found to be heterozygotes.
One patient (Case No. 1) had a post-operative pulmonary embolism. During her pregnancies, the prothrombin time values did not change.
- Adamis O. M. Rapid method for determination of plasma fibrinogen. Proc. Soc. exp. Biol. (N. Y.) 103: 107 1960;
- Alexander B, Goldstein R, Landwehr G, Cook C. D. Congenital SPCA Deficiency: A hitherto unrecognized coagulation defect with hemorrhage rectified by serum and serum fractions. J. clin. Invest 30: 596 1951;
- Hall G. A, Rapaport S. I, Ames S. B. A clinical and family study of hereditary proconvertin (factor VII) deficiency. Amer. J. Med 37: 172 1964;
- Koller F. Importance of coagulopathies for genetics in general. In: Proceedings of the Seventh Congress International Society of Hematology. Vol. 1 170-175 Grune & Stratton; New York: 1968. (cited by Owen et al. 1964).
- Kroll A. J, Alexander B, Cochios F, Pechet L. Hereditary deficiencies of clotting factors VII and X associated with carotidbody tumors. New Engl. J. Med 270: 6 1964;
- Marder V, Schulman N. R. Clinical aspects of congenital factor VII deficiency. Amer. J. Med 37: 182 1964;
- Owen Jr. G. A, Amundsen M. A, Thomson Jr. J. H, Spittell Jr. J. A, Bowie E. J. W, Stilwell G. G, Hewlett J. S, Mills S. D, Sauer W. G, Gage R. P. Congenital deficiency of factor VII (Hypoconvertinemia). Amer. J. Med 37: 71 1964;
- Voss D, Waaler B. A. Congenital Hypoproconvertinemia. A report on 12 cases with total deficiency and 19 cases with partial deficiency. Thrombos. Diathes. haemorrh. (Stuttg.) 04: 375 1959;