Thromb Haemost 1969; 21(01): 196-202
DOI: 10.1055/s-0038-1653528
Originalarbeiten - Original Articles - Travaux Originaux
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Erythrocyte Sedimentation and Soluble Fibrin Monomer Complexes

B Lipiński1)
1  Department of Physiological Chemistry, Medical School, Białystok, Poland
,
K Worowski
1  Department of Physiological Chemistry, Medical School, Białystok, Poland
,
M Myśliwiec
1  Department of Physiological Chemistry, Medical School, Białystok, Poland
,
R Farbiszewski
1  Department of Physiological Chemistry, Medical School, Białystok, Poland
› Author Affiliations
Further Information

Publication History

Publication Date:
28 August 2018 (online)

Summary

It is shown in the present work that highly significant correlation (r = 0.836) exists between the level of SFMC and the erythrocyte sedimentation rate in blood of 56 patients. No correlation of ESR with fibrinogen content was observed in 1 patient during the post-operative period, as well as in the group of experimentally infected rabbits. Administration of fibrinolysis inhibitors into rabbits (EACA, IP-315, HgCl2) caused in all cases a significant increase in ESR and in plasma SFMC with unrelated elevation of the fibrinogen level. Protamine sulphate added to whole blood with high ESR to final concentration 1 mg/ml of blood completely abolished the sedimentation of erythrocytes. A hypothesis is formulated according to which red cells interacting with SFMC increase their sedimentation rate.

1) Present adress: Department of Biochemistry, Postgraduate Medical School, Marymoncka 99, Warszawa, Poland.