PDF herunterladen
Thromb Haemost 1969; 21(01): 151-158
DOI: 10.1055/s-0038-1653520
Originalarbeiten - Original Articles - Travaux Originaux
Schattauer GmbH

Prevention by a Glucocorticoid of the Thrombotic and Hemorrhagic Tendencies Consecutive to Shock and Surgical Intervention in Rat[*]

S Renaud   1)
1   Laboratory of Experimental Pathology Montreal Heart Institute and Department of Pathology, University of Montreal
,
J. G Latouk   2)
1   Laboratory of Experimental Pathology Montreal Heart Institute and Department of Pathology, University of Montreal
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
26. Juli 2018 (online)

    Lizenzen und Reprints

Summary

Rats pretreated with acenocoumarin present a high incidence of hemorrhages from one to three days after an endotoxemic shock or a surgical intervention. The onset of hemorrhages is concomitant with a marked decrease in the platelet count and a considerable increase in the prothrombin time and the plasma clotting time. These hemorrhages as well as the changes in the parameters examined could be completely prevented by administration of triamcinolone at high doses (4 mg/kg), 2 hrs before and 2 hrs after the shock or the intervention.

Three days after the induction of a traumatic shock in hyperlipemic rats the count and adhesiveness of blood platelets was markedly increased. At this time, the intravenous injection of an endotoxin (S. typhosa lipopolysaccharide) induced a much higher incidence of large phlebothromboses in these traumatized rats than in the control animals. Here again, administration of high doses of triamcinolone could completely block the consequences of the traumatic shock, namely the changes in the platelet count and adhesiveness and the increased thrombotic tendency.

* Supported by Grant Mt-1444 from the Medical Research Council and a Grant from the Quebec Heart Foundation.


1) Scholar of the Medical Research Council.


2) Fellow of the Canadian Heart Foundation.


 

  • References

  • 1 Cliffton E. E. I-Evidence that a hypercoagulable state precedes massive oozing during and after major surgery. II. Effect of epsilon-aminocaproic acid (EACA) in control of surgical oozing. Bibl. haemat. (Basel) 23: 1264 1965;
    PubMedGoogle Scholar
  • 2 Meyerowitz B. R. Venous thrombosis in surgical patients. Amer. J. Surg 113: 520 1967;
    CrossrefPubMedGoogle Scholar
  • 3 Dawbarn R. V, Earlain F, Evans W. H. The relation of the blood platelets to thrombosis after operation and parturition. J. Path. Bact 31: 833 1928;
    CrossrefPubMedGoogle Scholar
  • 4 Egeberg O. Changes in the coagulation system following major surgical operations. Acta med. scand 171: 679 1962;
    PubMedGoogle Scholar
  • 5 Davidson E, Tomlin S. The levels of the plasma coagulation factors in the postoperative period. Thrombos. Diathes. haemorrh. (Stuttg) 10: 81 1963;
    PubMedGoogle Scholar
  • 6 Ham J. M, Slack W. W. Platelet adhesiveness after operation. Brit. J. Surg 54: 385 1967;
    CrossrefPubMedGoogle Scholar
  • 7 Wright H. P. Changes in the adhesiveness of blood platelets following parturition and surgical operations. J. Path. Bact 54: 461 1942;
    CrossrefPubMedGoogle Scholar
  • 8 Perkins H. A, Osborn J. J, Gerbode F. The management of abnormal bleeding following extracorporeal circulation. Ann. intern. Med 51: 658 1959;
    CrossrefPubMedGoogle Scholar
  • 9 Gilbert J. W, Bronson W. R, Brecher G. Incidence of bleeding in cardiac surgery with extracorporeal circulation. Ann. N. Y. Acad. Sci 115: 302 1964;
    PubMedGoogle Scholar
  • 10 Shapiro S, Wherwin B, Gordimer H. Postoperative thrombo-embolization: platelet count and prothrombin time after surgical operations. Ann. Surg 116: 175 1942;
    CrossrefPubMedGoogle Scholar
  • 11 Latour J. G, Renaud S. Blood platelet fluctuation consecutive to trauma and surgical intervention in the rat, a possible stress effect. Canad. J. Physiol. Pharmacol 44: 581 1966;
    CrossrefPubMedGoogle Scholar
  • 12 Renaud S, Latour J. G. Role of the pituitary-adrenocortical system in the stress-induced blood platelet fluctuation. Canad. J. Physiol. Pharmacol 44: 589 1966;
    CrossrefPubMedGoogle Scholar
  • 13 Latour J. G, Renaud S. Prevention by glucocorticoid of various blood parameter changes following surgical intervention and endotoxin administration in rat. Canad. M. A. J 100: 20 1969;
    PubMedGoogle Scholar
  • 14 Renaud S. Endotoxin induced hepatic vein thrombosis in hyperlipemic rats. Sequence of events. Lab. Invest 14: 424 1965;
    PubMedGoogle Scholar
  • 15 Renaud S, Allard C, Latour J. G. Influence of the type of dietary saturated fatty acid on lipemia, coagulation and the production of thrombosis in the rat. J. Nutr 90: 433 1966;
    CrossrefPubMedGoogle Scholar
  • 16 Hellem A. J. The adhesiveness of human blood platelets in vitro. Scand. J. clin. Lab. Invest 72 (Suppl. 51) 1-111 1960;
    PubMedGoogle Scholar
  • 17 Levine J. B, Zak B. Adaptation of the “Automated determination of serum total cholesterol”. Clin. Chim. Acta 10: 381 1964;
    CrossrefPubMedGoogle Scholar
  • 18 Renaud S. Thrombogenicity and atherogenicity of dietary fatty acids in rat. J. atheroscl. Res 08: 625 1968;
    CrossrefPubMedGoogle Scholar
  • 19 Jaques L. B. Spontaneous hemorrhage with anticoagulants. Circulation 25: 130 1966;
    PubMedGoogle Scholar
  • 20 Lucas O. N, Jaques L. B. Effects of EACA in spontaneous hemorrhage due to stress with anticoagulants in rats. Canad. J. Physiol. Pharmacol 42: 803 1964;
    CrossrefPubMedGoogle Scholar
  • 21 Van Gauwenberge H, Jaques L. B. Haemorrhagic effect of ACTH with anticoagulants. Canad. M. A. J 79: 536 1958;
    PubMedGoogle Scholar
  • 22 Jaques L. B. Stress and multiple factor etiology of bleeding. Ann. N. Y. Acad. Sci 115: 78 1964;
    PubMedGoogle Scholar
  • 23 Holswade G. R, Nachman R. L, Killip T. Thrombocytopathies in patients with open heart surgery: preoperative treatment with corticosteroids. Arch. Surg 94: 365 1967;
    CrossrefPubMedGoogle Scholar