Thromb Haemost 1969; 21(01): 129-133
DOI: 10.1055/s-0038-1653517
Originalarbeiten - Original Articles - Travaux Originaux
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In Vivo and In Vitro Binding of Factor VIII to Human Platelets[*]

Margaret Howell Karpatkin
1  Department of Medicine, New York University Medical School and the American National Red Cross Research Laboratory, New York, N. Y. 10016
,
S Karpatkin
1  Department of Medicine, New York University Medical School and the American National Red Cross Research Laboratory, New York, N. Y. 10016
› Author Affiliations
Further Information

Publication History

Publication Date:
10 June 2018 (online)

Summary

Human platelets were tested for the presence of factor VIII employing a modified partial thromboplastin system. Factor VIII was present on the surface of normal platelets after they had been washed five times in human Ringer solution containing 0.1 mM EDTA. Washed platelets from VIII deficient patients adsorbed factor VIII from normal plasma both in vitro and in vivo.

* Supported in part by a grant-in-aid from the New York Heart Association.