Thromb Haemost 1969; 21(01): 134-143
DOI: 10.1055/s-0038-1653516
Originalarbeiten - Original Articles - Travaux Originaux
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Plasma Fibrin Stabilising Factor (F. S. F.) Activity in Normal Subjects and Patients with Chronic Liver Disease

W. D Walls
1  Department of Medicine, The University of Leeds, The General Infirmary, Leeds, 1
,
M. S Losowsky
1  Department of Medicine, The University of Leeds, The General Infirmary, Leeds, 1
› Author Affiliations
Further Information

Publication History

Publication Date:
10 June 2018 (online)

Summary

A kinetic method for the quantitative estimation of plasma F.S.F. activity is described and discussed.

This method was applied to normal subjects and to patients with chronic liver disease. The plasma F.S.F. activity was uninfluenced by either sex or age, and the normal range has been defined.

A significant decrease in plasma F.S.F. activity was observed in patients with chronic liver disease. Subnormal levels of activity were found in 25% of such patients but were unrelated to episodes of abnormal haemorrhage. Plasma F.S.F. activity tended to be lower in patients with disease of greater clinical severity. In 2 patients showing clinical improvement there was an increase in plasma F. S. F. activity.

It was confirmed that plasma fibrinogen levels increase with age.