On the Effect on Human Thrombocytes of Synthetic Organic Fibrinolytic Compounds^[*]

Summary

The effect of various synthetic organic fibrinolysis-inducing compounds was investigated on platelets in plasma and on washed platelets. To a varying degree the com pounds induced a concentration-dependent platelet aggregation. Some at higher molarities cause lysis of platelets. The same molecular modifications which reduce the fibrinolytic activity also seem to reduce the effects of the compounds on platelets. Platelet aggregation by the compounds was reduced by adenosine, adenosine monophosphate, and some other ADP-inhibitors, but there was no proof that the compounds act by releasing ADP from the platelets. With fluorescent compounds their attachment to platelets was demonstrated.

^* Supported by a grant-in-aid from the American Heart Assoc. and grants HE 5638, HE 9985 National Heart Institute USPHS.

¹⁾ Recipient Scholarship University of Buenos Aires, Argentina.

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