Thromb Haemost 1969; 21(01): 026-034
DOI: 10.1055/s-0038-1653506
Originalarbeiten - Original Articles - Travaux Originaux
Schattauer GmbH

Plasmatic and Thrombocytic Anti-Plasmins and Anti-Activators II.

G. J. H den Ottolander
1  Department of Internal Medicine, Municipal General Hospital Bergweg and the Department of Chemical Pathology, Medical Faculty Rotterdam, Rotterdam (The Netherlands)
,
B Leijnse
1  Department of Internal Medicine, Municipal General Hospital Bergweg and the Department of Chemical Pathology, Medical Faculty Rotterdam, Rotterdam (The Netherlands)
,
H. M. J Cremer-Elfrink
1  Department of Internal Medicine, Municipal General Hospital Bergweg and the Department of Chemical Pathology, Medical Faculty Rotterdam, Rotterdam (The Netherlands)
› Author Affiliations
This investigation was supported by a grant of The Netherlands Organisation for the advancement of pure research (Z. W. O.).
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Publication History

Publication Date:
28 August 2018 (online)

Summary

Values for inhibitors in plasma and in platelets against plasmin and against different activators were measured in normal test persons. The influence of freezing and thawing, of heating to 60° C and of destruction in other ways was assessed. The reaction pattern of all these inhibitors was established. It appears that there are differences in behaviour amongst these inhibitors. In patients with a high and with a low anti-UK there was no correlation with the levels of inhibitors directed against blood activator, obtained in several ways, SK and tissue activator.

The conclusion is that anti-UK is not representative for anti-activator activity in general. There are indications that blood activator liberated with different stimuli is one substance.