Thromb Haemost 1969; 21(01): 020-025
DOI: 10.1055/s-0038-1653505
Originalarbeiten - Original Articles - Travaux Originaux
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Stress Induced Release of Plasminogen Activator from Lysosomes

E. L Beard
1  Department of Biological Sciences, Loyola University, New Orleans, Lα.
,
R. W Busuttil
1  Department of Biological Sciences, Loyola University, New Orleans, Lα.
,
S. K Gottshalk
1  Department of Biological Sciences, Loyola University, New Orleans, Lα.
› Author Affiliations
This study was supported by grants from the Louisiana Heart Association and Cancer Association Research of Greater New Orleans.
Further Information

Publication History

Publication Date:
28 August 2018 (online)

Summary

Mild hemorrhage was found to bring about a slight increase in the plasminogen activator activity of the blood serum of albino rats. This change coincided with a minor increase in the plasminogen activator activity of the liver microsomes of these rats and a significant increase in that of the liver lysosomes. Presumably the stress was sufficient to increase lysosomal permeability allowing for a greater outflow of plasminogen activator into the body fluids.

Drum trauma and acid phosphatase injections brought about a similar release of plasminogen activator and acid phosphatase which intensified when the two were applied together. Rats which had previously been made resistant to drum trauma responded only slightly to either stress alone but their resistance was overcome when both stresses were applied together.