Thromb Haemost 1981; 46(03): 623-625
DOI: 10.1055/s-0038-1653432
Original Article
Schattauer GmbH Stuttgart

Comparison of Progressive Antithrombin Activity and the Concentration of Three Thrombin Inhibitors in Nephrotic Syndrome

B Boneu
*   The Laboratoire d’Hémostase, Centre Régional de Transfusion Sanguine, Hopital Purpan Toulouse, France
,
F Bouissou
**   The Service de Pédiatrie C2, Hopital Purpan Toulouse, France
,
M Abbal
*   The Laboratoire d’Hémostase, Centre Régional de Transfusion Sanguine, Hopital Purpan Toulouse, France
,
P Sie
*   The Laboratoire d’Hémostase, Centre Régional de Transfusion Sanguine, Hopital Purpan Toulouse, France
,
C Caranobe
*   The Laboratoire d’Hémostase, Centre Régional de Transfusion Sanguine, Hopital Purpan Toulouse, France
,
P Barthe
**   The Service de Pédiatrie C2, Hopital Purpan Toulouse, France
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Publikationsverlauf

Received 27. April 1981

Accepted 29. Juli 1981

Publikationsdatum:
05. Juli 2018 (online)

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Summary

In order to compare the plasmatic progressive antithrombin activity to the concentration of three thrombin inhibitors, antithrombin III (AT III), α2 macroglobulin (α2, M), α1 anti-trypsin (α1 AT) in nephrotic syndrome, a prospective study was carried out on a group of 28 children affected with the disease. A dramatic reduction of the level of AT III and of α1 AT, two inhibitors of molecular weight close to that of albumin, was observed. The decreased level of AT III was counterbalanced by an increase in α2 M. This phenomenon accounts for the increased progressive antithrombin activity observed in all the affected children. It is suggested that the above compensatory mechanism explains the absence of thrombotic accidents in this series and that the benefit of heparin therapy is doubtful in these conditions.