Thromb Haemost 1981; 46(02): 535-537
DOI: 10.1055/s-0038-1653404
Original Article
Schattauer GmbH Stuttgart

The Thrombolytic Activity of Streptokinase in the Rabbit

P D English
The Beecham Pharmaceuticals Research Division, Biosciences Research Centre, Great Burgh, Epsom, Surrey, U.K
,
R A G Smith
The Beecham Pharmaceuticals Research Division, Biosciences Research Centre, Great Burgh, Epsom, Surrey, U.K
,
R J Dupe
The Beecham Pharmaceuticals Research Division, Biosciences Research Centre, Great Burgh, Epsom, Surrey, U.K
,
J Green
The Beecham Pharmaceuticals Research Division, Biosciences Research Centre, Great Burgh, Epsom, Surrey, U.K
,
M J Hibbs
The Beecham Pharmaceuticals Research Division, Biosciences Research Centre, Great Burgh, Epsom, Surrey, U.K
› Author Affiliations
Further Information

Publication History

Received 24 March 1981

Accepted 26 May 1981

Publication Date:
05 July 2018 (online)

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Summary

The activity of streptokinase (SK) has been examinEd in a rabbit model of venous thrombosis. Significant thrombolysis was observed at low doses of SK without evidence of systemic activation of the fibrinolytic system. The origidn of the specificity of SK-induced fibrinolysis in the rabbit was explored, using a chromogenic substrate coupled assay to measure the enhancement of plasmin generation in the presence of rabbit fibrin. The results obtained suggest that rabbit fibrin influences the fibrinolytic system at three points, viz: the assembly of an activator complex from rabbit plasminogen and SK; the activity of that activator complex towards further rabbit plasminogen; and the activity of the resulting rabbit plasmin in the presence of plasma inhibitors.