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Thromb Haemost 1981; 46(01): 126
DOI: 10.1055/s-0038-1652335
Coagulation – VIII: Factor VIII/von Willebrand, Factor IX
Schattauer GmbH Stuttgart

Association Between Plasma Concentration Of Factor VIII Related Antigen, ABO Blood Type And Lewis Blood Type

Authors

  • K H Orstavik

    Institute of Medical Genetics, University of Oslo, Oslo, Norway

  • P Magnus

    Institute of Medical Genetics, University of Oslo, Oslo, Norway
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Publication History

Publication Date:
24 July 2018 (online)

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Individuals with blood type 0 have a lower plasma concentration of factor VIII than individuals with blood type A. Since the Lewis blood type system and the ABO blood type system are related, we looked for a possible association between the plasma concentration of factor VIII and Lewis blood type.

Plasma concentration of factor VIII related antigen (FVIIIR:Ag) was determined by the Laurell electroimmunoassay in 333 individuals. These individuals were identical and fraternal twins who had been bled as part of a twin study on coagulation factors. The association between factor VIII and ABO blood type was confirmed since a significantly lower concentration of FVIIIR:Ag was found in individuals with blood type 0 (77%) than in individuals with blood type A (106%). Lewis blood type had no significant effect on the concentration of FVIIIR:Ag when the whole material was examined. Within individuals with blood type 0, a much lower concentration of FVIIIR:Ag was found in individuals with Lewis blood type Le(a-b-) (52%) compared to individuals with Lewis blood type Le(a-b+) (80%) or Le(a+b-) (88%).

The possibility that individuals with blood type 0 and no Lewis antigens have a low plasma concentration of factor VIII may have implications for the detection of carriers of hemophilia A.