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Thromb Haemost 1977; 38(02): 0457-0464
DOI: 10.1055/s-0038-1651851
Original Article
Schattauer GmbH

Spontaneous Atrial Thrombosis in Aged Syrian Hamsters II. Hemostasis

W. Jean Dodds
1   Division of Laboratories and Research, New York State Department of Health, Albany, NY 12201, U.S.A. Reprint requests should be directed to the author(s).
,
Sharon L. Raymond
1   Division of Laboratories and Research, New York State Department of Health, Albany, NY 12201, U.S.A. Reprint requests should be directed to the author(s).
,
Ann C. Moynihan
1   Division of Laboratories and Research, New York State Department of Health, Albany, NY 12201, U.S.A. Reprint requests should be directed to the author(s).
,
Donald N. McMartin
1   Division of Laboratories and Research, New York State Department of Health, Albany, NY 12201, U.S.A. Reprint requests should be directed to the author(s).
› Author Affiliations
Further Information

Publication History

Received 25 October 1976

Accepted 26 May 1977

Publication Date:
04 July 2018 (online)

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Summary

Coagulation and fibrinolysis were studied in a colony of aged Syrian hamsters with spontaneous atrial thrombosis, and the results are consistent with concomitant consumption coagulopathy. In comparison to age- and sex-matched hamsters from the same colony, those with atrial thrombi had significantly prolonged prothrombin and partial thromboplastin times, reduced levels of factors II, VII, VIII and X activities and plasminogen; and concentrations of fibrinogen-fibrin split products in excess of 80 μg/ml. Hematocrits of the thrombosed animals were significantly decreased, total plasma proteins were increased, leukocyte counts were within normal limits, and platelet counts were about half those of the controls. Thrombosed hamsters had significantly reduced plasma albumin content, increased γ1-, β-, and γ-globulins, and reduced A/G ratios.

Aged sick hamsters without demonstrable thrombi also had reduced coagulation and fibrinolytic activities and platelet counts, but their fibrinogen levels were markedly elevated, and fibrinogen-fibrin split products were either absent or present in trace amounts. This suggests an earlier and/or less acute form of the thrombotic process.

 

  • References

  • 1 Bernhardt B, Valletta M, Brook J, Lejnieks I. 1972; Case report. Amyloidosis with factor X deficiency. American Journal of The Medical Sciences 264: 411.
    CrossrefPubMedGoogle Scholar
  • 2 Bowie E. J. W, Thompson Jr. J. H, Didisheim P, Owen C. A. 1971. Mayo Clinic Laboratory Manual of Hemostasis. W. B. Saunders; Philadelphia.:
    Google Scholar
  • 3 Cooper H. A, Bowie E. J. W, Owen Jr. C. A. 1973; Chronic induced intravascular coagulation in dogs. American Journal of Physiology 225: 1355.
    PubMedGoogle Scholar
  • 4 Dodds W. J, Pickering R. J. 1972; The effect of cobra venom factor on hemostasis in guinea pigs. Blood 40: 400.
    PubMedGoogle Scholar
  • 5 Dodds W. J, Raymond S. L, McMartin D. N. 1975; a Atrial thrombosis and consumption coagulopathy in aged Syrian hamsters. Federation Proceedings 34: 221.
    PubMedGoogle Scholar
  • 6 Dodds W. J, Moynihan A. C, Benson R. E, Hall C. A. 1975; b The value of age- and sex-matched controls for coagulation studies. British Journal of Haematology 29: 305.
    CrossrefPubMedGoogle Scholar
  • 7 Galbraith P. A, Sharma N, Parker W. L, Kilgour J. M. 1974; Acquired factor X deficiency. Altered plasma antithrombin activity and association with amyloidosis. Journal of American Medical Association 230: 1658.
    CrossrefPubMedGoogle Scholar
  • 8 Johnson A. J, Kline D. L, Alkjaersig N. 1969; Assay methods and standard preparations for plasmin, plasminogen, and urokinase in purified systems. Thrombosis et Diathesis Haemorrhagica 21: 259.
    PubMedGoogle Scholar
  • 9 McMartin D. N. 1977; Spontaneous atrial thrombosis in aged Syrian hamsters. I. Incidence and pathology. Thrombosis and Haemostasis 38: 447.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 10 Merskey C. 1973; Defibrination syndrome or...?. Blood 41: 599.
    PubMedGoogle Scholar
  • 11 Merskey C, Johnson A. J, Kleiner G. J, Wohl H. 1967; The defibrination syndrome: Clinical features and laboratory diagnosis. British Journal of Haematology 13: 528.
    CrossrefPubMedGoogle Scholar
  • 12 Merskey C, Lalezari P, Johnson A. J. 1969; A rapid, simple sensitive method for measuring fibrinolytic split products in human serum. Proceedings of the Society for Experimental Biology and Medicine 131: 871.
    PubMedGoogle Scholar
  • 13 Ratnoff O. D, Menzie C. 1951; A new method for the determination of fibrinogen in small samples of plasma. Journal of Laboratory and Clinical Medicine 37: 316.
    PubMedGoogle Scholar
  • 14 Raymond S. L, Dodds W. J. 1975; Characterization of the fawn-hooded rat as a model for hemostatic studies. Thrombosis et Diathesis Haemorrhagica 33: 361.
    PubMedGoogle Scholar
  • 15 Schalm O. W, Jain N. C, Carroll E. J. 1975. Veterinary Hematology. 3rd edition. Lea & Febiger; Philadelphia.:
    Google Scholar
  • 16 Selroos O, Pettersson T. 1973; Platelet values in amyloidosis. Scandinavian Journal of Rheumatology 2: 97.
    CrossrefPubMedGoogle Scholar
  • 17 Sichuk G, Bettigole R. E, Der B. K, Fortner J. G. 1965; Influence of sex hormones on thrombosis of left atrium in Syrian (golden) hamsters. American Journal of Physiology 208: 465.
    PubMedGoogle Scholar
  • 18 Van Dam F. E, De Pauw B. E, Schultjes C. P. M, Veuger A. J. L. M. 1975; Isolated factor X deficiency in amyloidosis. Case report and review of the literature. Netherlands Journal of Medicine 18: 129.
    PubMedGoogle Scholar