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Thromb Haemost 1995; 73(01): 001-005
DOI: 10.1055/s-0038-1651666
Review Article
Schattauer GmbH Stuttgart

Post-Partum Factor VIII Inhibitors

A Review of the Literature with Special Reference to the Value of Steroid and Immunosuppressive Treatment
I Hauser
1   The First Dept. of Internal Medicine, Division of Hematology and Blood Coagulation, University of Vienna, Vienna, Austria
,
B Schneider
2   The Institute of Medical Statistics and Documentation, University of Vienna, Vienna, Austria
,
K Lechner
1   The First Dept. of Internal Medicine, Division of Hematology and Blood Coagulation, University of Vienna, Vienna, Austria
› Author Affiliations
Further Information

Publication History

Received 03 May 1994

Accepted after resubmission 29 September 1994

Publication Date:
09 July 2018 (online)

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Summary

In a retrospective study 51 published cases of post-partum factor VIII inhibitors were analyzed with regard to the outcome according to treatment. The overall outcome was favorable with 97% survival at two years. The probability of complete remission (CR, absence of the inhibitor and normalization of factor VIII activity) was almost 100% at 30 months. Steroid treatment appears to be not superior to no treatment, but patients treated with immunosuppressive drugs (cyclophosphamide, azathioprine, 6-mercaptopurine) had a significantly shorter time to CR. In the absence of a randomized trial this analysis may be helpful for decision-making in women with factor VIII post-partum inhibitors. Because of the retrospective study design, conclusions have to be regarded with caution.

 

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