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Thromb Haemost 1995; 73(01): 001-005
DOI: 10.1055/s-0038-1651666
DOI: 10.1055/s-0038-1651666
Review Article
Post-Partum Factor VIII Inhibitors
A Review of the Literature with Special Reference to the Value of Steroid and Immunosuppressive TreatmentAuthors
Further Information
Publication History
Received 03 May 1994
Accepted after resubmission 29 September 1994
Publication Date:
09 July 2018 (online)
Summary
In a retrospective study 51 published cases of post-partum factor VIII inhibitors were analyzed with regard to the outcome according to treatment. The overall outcome was favorable with 97% survival at two years. The probability of complete remission (CR, absence of the inhibitor and normalization of factor VIII activity) was almost 100% at 30 months. Steroid treatment appears to be not superior to no treatment, but patients treated with immunosuppressive drugs (cyclophosphamide, azathioprine, 6-mercaptopurine) had a significantly shorter time to CR. In the absence of a randomized trial this analysis may be helpful for decision-making in women with factor VIII post-partum inhibitors. Because of the retrospective study design, conclusions have to be regarded with caution.
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