Relación entre ratio digital (2D:4D) y severidad preoperatoria del cáncer de próstata

Resumen

Objetivo La ratio digital del segundo y cuarto dedo de la mano (2D:4D) es un marcador de la exposición a andrógenos prenatal que presenta un dimorfismo sexual en mamíferos, siendo menor en hombres que en mujeres. El objetivo de nuestro estudio fue analizar la asociación entre la ratio 2D:4D (como marcador indirecto del ambiente hormonal intrauterino) y la severidad preoperatoria del cáncer de próstata (CaP).

Material y métodos Se trata de un estudio transversal que incluyó 118 pacientes intervenidos de CaP y con confirmación histológica por biopsia desde abril de 2007 hasta julio de 2015. A cada paciente se le realizó una exploración física y se midió desde la base de la falange proximal hasta el extremo de la falange distal tanto en el cuarto como en el segundo dedo de la mano derecha. La asociación entre la ratio 2D:4D y los indicadores de severidad prequirúrgicos de CaP se realizaron mediante test de medias, correlación de Spearman y regresión lineal simple.

Resultados La ratio 2D:4D se asoció significativamente con el PSA prequirúrgico (p = 0,023) y con el porcentaje de cilindros afectados en la biopsia (p = 0,05)

Conclusión Nuestros resultados sugieren que una mayor exposición androgénica prenatal, reflejado en una ratio 2D:4D disminuida, estaría asociada con una mayor severidad prequirúrgica del CaP.

Abstract

Objective Digit ratios, especially 2D:4D ratio, is a marker for prenatal androgen exposure that shows sexual dimorphism in mammals, being lower in men than in women. The aim of this study was to assess the associations between the2D:4D ratio (as an indirect marker for prenatal androgen environment) and preoperative severity of prostate cancer (PCa).

Material and Methods This is a cross-sectional study of 118 operated PCa patients with confirmed biopsy of the tumor recruited between April 2007 and July 2015. All subjects underwent a physical examination, and the length from the bases of the second or fourth proximal phalanxes to the tips of the corresponding distal phalanxes on the right hand were measured. Associations between 2D:4D ratio and markers of PCa preoperative severity were evaluated using mean test scores, Spearman correlations and simple linear regression.

Results 2D:4D ratio was statistically significantly associated with preoperative PSA levels (p = 0.023) and the percentage of biopsy cylinders affected (p = 0.05).

Conclusions Our results suggest that higher prenatal androgen exposure, reflecting a lower 2D:4D ratio, may be associated with higher preoperative severity of PCa.

Palabras Clave

neoplasia prostática - ratio digital - antígeno prostático específico - biopsia - cilindros - severidad preoperatoria

Keywords

neoplasm prostatic - digit ratio - prostate-specific antigen - biopsy - cylinders - preoperative severity

Protección de personas y animales

Los autores declaran que para esta investigación, no se han realizado experimentos en seres humanos ni en animales.

Confidencialidad de los datos

Los autores declaran que han seguido los protocolos de su centro de trabajo sobre la publicación de datos de pacientes.

Derecho a la privacidad y consentimiento informado

Los autores han obtenido el consentimiento informado de los pacientes y/o sujetos referidos en el artículo. Este documento obra en poder del autor de correspondencia.

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