PDF herunterladen
Thromb Haemost 1968; 20(03/04): 596-602
DOI: 10.1055/s-0038-1651303
Originalarbeiten – Original Articles – Travaux Originaux
Schattauer GmbH

Thrombus Formation Time in Hemophilia An In Vitro Study

N. D Giordano
1   The Research Department, Huron Road Hospital Cleveland, Ohio
,
M Radivoyevitch
1   The Research Department, Huron Road Hospital Cleveland, Ohio
,
E Goodsitt
1   The Research Department, Huron Road Hospital Cleveland, Ohio
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
27. Juni 2018 (online)

Auch verfügbar auf
 als PDF herunterladen  Lizenzen und Reprints

Summary

An in vitro study was performed with 14 hemophilia-A patients, using a simple wheel with an electrically driven motor to form thrombi.

The findings are discussed in relationship to normal thrombi and a direct comparison was made in regard to rate of thrombus formation, thrombus length and morphological differences.

A relationship between the above and clinical severity of the disease with some speculations on the possible role played by white and red cells on thrombus formation time, was also presented.

 

  • References

  • 1 Ardlie N.G, Kinlough R.L, Schwartz G.J. In Vitro Thrombosis and Platelet Aggregation in Myocardial Infarction. Brit. med. J 1966; 1: 888
    CrossrefPubMedSuche in Google Scholar
  • 2 Barkhan P, Silver M.J. Biological Activities of Human Platelets. Biochemical. Physiological and Clinical Aspects. Prog. Hemat 1962; 3: 170
    PubMedSuche in Google Scholar
  • 3 Bizzozero J. Über einen neuen Formbestandteil des Blutes und dessen Rolle bei der Thrombose und der Blutgerinnung. Virchows Arch. path. Anat 1882; 90: 261
    CrossrefPubMedSuche in Google Scholar
  • 4 Born G.V.R. Platelets in thrombogenesis : Mechanism and inhibition of platelet aggregation. Ann. roy. Coll. Surg. Engl 1965; 36: 200
    PubMedSuche in Google Scholar
  • 5 Born G.V.R. Inhibition of Thrombogenesis by Inhibition of Platelet Aggregation. Pathogenesis and Treatment of Thromboembolic Diseases. International Symposium Basle; Switzerland: 1965
    Suche in Google Scholar
  • 6 Brecher G, Cronkite E.P. Estimation of the Number of Platelets by Phase Microscopy. J. appl. Physiol 1950; 3: 365
    CrossrefPubMedSuche in Google Scholar
  • 7 Brinkhous K.M. Clotting defect in hemophilia. Deficiency in a plasma factor required for platelet utilization. Proc. Soc. exp. Biol. (N. Y.) 1947; 66: 117
    CrossrefPubMedSuche in Google Scholar
  • 8 Crawford N, Sutton M, Horsfield G.I. Platelets in the Carcinoid Syndrome. A Chemical and Ultrastructural Investigation. Brit. J. Haemat 1967; 13: 181
    CrossrefPubMedSuche in Google Scholar
  • 9 Cronberg S, Robertson B, Nilsson I.M, Nilêhn J.E. Suppressive Effect of Dextran on Platelet Adhesiveness. Thrombos. Diathes. haemorrh. (Stuttg.) 1966; 16: 384
    PubMedSuche in Google Scholar
  • 10 Gross M.J. Effect of fibrinogen on the aggregation of platelets by adenosine diphosphate. Thrombos. Diathes. haemorrh. (Stuttg.) 1964; 12: 524
    PubMedSuche in Google Scholar
  • 11 Eberth J.C, Schimmelbush C. Experimentelle Untersuchungen über Thrombose. IL Die Entstehung von Thromben in größeren Gefäßen von Säugetieren. Virchows Arch. path. Anat 1886; 105: 331
    CrossrefPubMedSuche in Google Scholar
  • 12 Gugler E, Lüscher E.F. Platelet Function in Congenital Afibrinogenemia. Thrombos. Diathes. haemorrh. (Stuttg.) 1965; 14: 361
    PubMedSuche in Google Scholar
  • 13 Hardisty R.M, Button R.A. Platelet Aggregation and the Availability of Platelet Factor 3. Brit. J. Haemat 1966; 12: 764
    CrossrefPubMedSuche in Google Scholar
  • 14 Harrison M.J.G, Emmons P.R, Mitchell J.R.A. The Effect of White Cells on Platelet Aggregation. Thrombos. Diathes. haemorrh. Stuttg 1966; 16: 105
    PubMedSuche in Google Scholar
  • 15 Hayem G. Sur le mécanisme de l’arrêt des hémorrhagies. C. R. Acad. Sci. (Paris) 1882; 95: 261
    PubMedSuche in Google Scholar
  • 16 Hoak J.G, Warner E.D, Connor W.E. Platelets. Fatty acids and Thrombosis. Circulat. Res 1967; 20: 11
    CrossrefPubMedSuche in Google Scholar
  • 17 Howell W.H, Cekada E.B. The cause of the delayed clotting in hemophilia blood. Amer. J. Physiol 1926; 78: 500
    PubMedSuche in Google Scholar
  • 18 Johnson S.A, van Horn D.L, Pederson H.J, Marr J. The Function of Platelets. A Review. Transfusion 1966; 6: 3
    CrossrefPubMedSuche in Google Scholar
  • 19 Karaca M, Stefanini M, Mele M. Studies on platelets. Chemical analysis of platelets from patients with congenital and acquired thrombocytopathy, with special reference to phospholipids. J. Lab. clin. Med 1966; 67: 229
    PubMedSuche in Google Scholar
  • 20 Lüscher E.F. Viscous Metamorphosis and clot retraction. Vox Sang 1956; 1: 133
    CrossrefPubMedSuche in Google Scholar
  • 21 Lüscher E.F. Platelets in Hemostasis and Thrombosis. Brit. J. Haemat 1967; 13: 1
    PubMedSuche in Google Scholar
  • 22 Marcus A.J, Zucker-Franklin D, Saßer L.B, Ullman H.L. Studies on Human Platelet Granules and Membranes. J. clin. Invest 1966; 45: 14
    CrossrefPubMedSuche in Google Scholar
  • 23 McLean J.F, Maxwell R.R, Hertler D. Fibrinogen and adenosine diphosphate-induced aggregation of platelets. Nature (Lond.) 1964; 202: 605
    CrossrefPubMedSuche in Google Scholar
  • 24 Minot G.R, Lee R.I. Blood platelets in hemophilia. Arch, intern. Med 1916; 17: 474
    PubMedSuche in Google Scholar
  • 25 Mustard J.F, Rowsell H.G, Lotz F, Hegardt B, Murphy E.A. The Effect of Adenine Nucleotides on Thrombus Formation. Platelet Count and Blood Coagulation. Exp. molec. Path 1966; 5: 43
    PubMedSuche in Google Scholar
  • 26 Mustard J.F, Rowsell H.C, Murphy E.A. Platelet Economy (Platelet Survival and Turnover). Brit. J. Haemat 1966. 12 (1) Jan.
    Suche in Google Scholar
  • 27 O’Brien J.R, Heywood J.B, Heady J.A. The Quantitation of Platelet Aggregation Induced by Four Compounds: A Study in Relation to Myocardial Infarction. Thrombos. Diathes. haemorrh. (Stuttg.) 1966; 16: 751
    PubMedSuche in Google Scholar
  • 28 Patek A.J, Stetson R.P. Hemophilia: The abnormal coagulation of the blood and its relation to the blood platelets. J. clin. Invest 1936; 15: 531
    CrossrefPubMedSuche in Google Scholar
  • 29 Pavlovsky M, Pavlovsky A. Study of Platelet Function in Hemophiliacs. In: Diffuse Intravascular Clotting. F. K. Schattauer; Stuttgart: 1965: p. 303
    Suche in Google Scholar
  • 30 Poole J.G.F. A study of artificial thrombi produced by a modification of Chandler's method. Quart. J. exp. Physiol 1959; 44: 377
    PubMedSuche in Google Scholar
  • 31 Quick A.J. Studies on the enigma of the hemostatic dysfunction of hemophilia. Amer. J. med. Sci 1947; 214: 272
    CrossrefPubMedSuche in Google Scholar
  • 32 Rodman N.F, Mason R.G, Painter J.G, Brinkhous K.M. Fibrinogen - Its Role in Platelet Agglutination and Agglutinate Stability. A Study of Congenital Afibrinogenemia. Lab. Invest 1966; 25: 641
    PubMedSuche in Google Scholar
  • 33 Rozenberg M.C, Firkin B.C. The Rate of Platelet Aggregation in Haemorrhagic Disease and Thrombosis. Scand. J. Haemat 1966; 3: 5
    PubMedSuche in Google Scholar
  • 34 Seegers W.H, Johnson S.A, Anderson G.F. Fourteenth Annual Symposium on Blood. Thrombos. Diathes. haemorrh. (Stuttg.) 1966; 15: 624
    PubMedSuche in Google Scholar
  • 35 Sharp A.A. Viscous metamorphosis of blood platelets. A study of the relationship to coagulation factors and fibrin formation. Brit. J. Haemat 1958; 4: 28
    CrossrefPubMedSuche in Google Scholar
  • 36 Sharp A. Experimental Platelet Thrombus. Pathogenesis and Treatment of Thromboembolic Diseases. International Symposium. Aug. 29 to Sept. 1. 1965: 109
    Suche in Google Scholar
  • 37 Tocantins L.M. Mammalian blood platelets in health and disease. Medicine 1938; 17: 155
    CrossrefPubMedSuche in Google Scholar
  • 38 Tocantins L.M. Hemophilic Syndromes and Hemophilia. Blood 1954; 9: 281
    PubMedSuche in Google Scholar
  • 39 Tocantins L.M, Holburn R.R, Carroll R.T. Coagulation of Blood. Methods of Study. Grune and Stratton; New York: 1955: p. 176
    Suche in Google Scholar