Lack of Evidence for a Thrombolytic Effect of Sodium Gluconate in Arteries

Summary

After Kopper (1966) reported that sodium gluconate induces thrombolysis, we tested the effect of this substance on 8 hrs old clots which had been artificially initiated in the femoral artery of cats. These clots can be lysed completely as previous experiments with streptokinase and urokinase have shown. During a 24 hrs continuous administration of sodium gluconate, in no animal a thrombolytic effect was observed. Kopper’s positive results, which were obtained primarily on venous clots, lead one to believe that possibly sodium gluconate liberates plasminogen activators from the endothelium of veins, where these are in high concentrations compared to the intima of arteries.

^* Substantial parts of the present paper will be used by K. Schniep as dissertation and submitted to the Department of Medicine at the University of Ulm.

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