Treatment of Thrombosis of the Central Retinal Vein with Streptokinase

G. J. H den Ottolander; A Craandijk

doi:10.1055/s-0038-1651284

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1968; 20(03/04): 415-419
DOI: 10.1055/s-0038-1651284

Originalarbeiten – Original Articles – Travaux Originaux

Schattauer GmbH

Treatment of Thrombosis of the Central Retinal Vein with Streptokinase

G. J. H den Ottolander

¹Department of Medicine, Municipal General Hospital, Bergweg, Rotterdam and the Eye Hospital Medical Faculty, Rotterdam

,

A Craandijk

¹Department of Medicine, Municipal General Hospital, Bergweg, Rotterdam and the Eye Hospital Medical Faculty, Rotterdam

› Author Affiliations

Abstract

PDF Download

Summary

In a double blind study of 5 heparin treated and 5 streptokinase treated patients with central retinal vein occlusions it would seem from the results based on visual acuity, ERG and EOG and fluorescence angiography that the heparin treated group were better off than the SK treated patients.

It therefore seems dubious whether streptokinase therapy affords such an important advantage over the convential heparin therapy in cases of central retinal vein occlusions. It must be stressed that a group of 10 patients is very small and that the observations made are probably not statistically significant.

PDF (803 kb)

References

References
1 Arden G.B, Barrada A, Kelsey J.H. New clinical test for retinal function based upon the standing potential of the eye. Brit. J. Ophthal 1962; 46: 449-467
2 Blix S. The effectiveness of activators in clot lysis with special reference to fibrinolytic therapy. A new method for determination of preformed clot lysis. Acta med. scand. Suppl 1962; 386
3 Cliffton E.E. Review of clinical experience with clot lysing agents. Amer. J. Cardiol 1960; 476
4 Craandijk A. Prospect in ophthalmology. Exe. med. (Amst.) 1968: 57-65
5 Hayreh S.S. Arterial insufficiency in retinal venous occlusion. Transactions of the Ophthalm. Soc. of the U. K 1964; 84: 586
6 Henkes H.E.A.Th.M.v. Balen: Periodical integration of retinal responses following repetitive light stimuli. Acta Ophthal. (Kbh.) Suppl 1962; 70: 147-155
7 Hiemeyer V. Thrombolytische Therapie bei akuten Gefäßverschlüssen. Dtsch. med. Wschr 1967; 92: 955
8 Howden G.D. The successful treatment of a case of central retinal vein thrombosis with intravenous fibrinolysis. Canad. med. Ass. J 1959; 81: 382
9 Jürgens J, Hess H, Seitz W. Thrombolytische Therapie. S.. F. K. Schattauer; Stuttgart: 1967: 154
10 Lindehe H.J, Masler S.R. Therapy of retinal vein occlusion. Use of fibrinolysin and anticoagulants. Amer. J. Ophthal 1961; 51: 456
11 Marx R. Bemerkungen zur Klinischen Anwendung der gereinigten Streptokinase. Behring -werke-MitteilungenH 1962; 41: 103
12 Morton W.R, Turnbull W. An unusual case of central retinal vein occlusion, treated successfully with intravenous fibrinolysin. Canad. med. Ass. J 1961; 85: 844
13 Oosterhuis J.A, Lammens A.J.J. Fluorescein photography of the ocular fundus. Ophthal-mologica (Basel) 1965; 149: 210
14 Paton A, Rubinstein K, Smith V.H. Arterial insufficiency in retinal venous occlusion. Transactions of the Ophthalm. Soc. of the U. K 1964; 84: 564
15 Roszman H. Die thrombolytische Behandlung von Gefäßverschlüssen der Netzhaut. Klin. Mbl. Augenheilk 1966; 149: 874
16 Schmutzler R, Koller F. Die Thrombolyse-Therapie. Ergebn. inn. Med. Kinderheilk 1965; 22: 158
17 Verstraete M, Vermijlen J, Amery A, Vermijlen C. Thrombolytic therapy with streptokinase using a standard dosage scheme. Brit. Med. J 1966; I: 454