Inhibition by Dipyridamole of Arterial Thrombosis in Rats

Summary

Thrombi in mesenteric arteries of the rat were produced by electric means. The effectiveness of 4 agents – heparin, aspirin, warfarin, and dipyridamole – in modifying arterial thrombosis was examined with this model. Heparin and aspirin had equivocal beneficial effects. Warfarin had a deleterious effect: the duration of complete occlusion was prolonged. In striking contrast, dipyridamole induced a marked shortening in the duration of complete thrombotic occlusion. On reinjection of the drug, occlusion was almost completely suppressed.

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