Thromb Haemost 1968; 20(01/02): 078-087
DOI: 10.1055/s-0038-1651250
Originalarbeiten – Original Articles – Travaux Originaux
Schattauer GmbH

Kinetic Aspects of the Interaction of Blood-Clotting Enzymes

VI. Localization of the Site of Blood-Coagulation Inhibition by the Protein Induced by Vitamin K Absence (PIVKA)

Authors

  • H. C Hemker

    1   Laboratory for Coagulation Biochemistry and Cardiovascular Biochemical Research, Depts of Haematology and Cardiology, Clinic for Internal Medicine, University Hospital, Leiden, The Netherlands
  • A. D Muller

    1   Laboratory for Coagulation Biochemistry and Cardiovascular Biochemical Research, Depts of Haematology and Cardiology, Clinic for Internal Medicine, University Hospital, Leiden, The Netherlands
Further Information

Publication History

Publication Date:
27 June 2018 (online)

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Summary

PIVKA, the circulating anticoagulant protein found in vitamin K deficiency can, on kinetical grounds, be recognized as an analogue of factor X. The existence of analogues of other vitamin K-dependent clotting factors cannot be ruled out, but need not be assumed to explain the experimental results.