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Thromb Haemost 1968; 20(01/02): 001-006
DOI: 10.1055/s-0038-1651243
Originalarbeiten – Original Articles – Travaux Originaux
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Radioimmunoassay of Fibrinogen and Its Proteolysis Products

K. J Catt
1   Department of Medicine, Monash University, Prince Henry’s Hospital, and University of Melbourne Department of Medicine, St. Vincent’s Hospital, Melbourne, Australia
,
J Hirsh
1   Department of Medicine, Monash University, Prince Henry’s Hospital, and University of Melbourne Department of Medicine, St. Vincent’s Hospital, Melbourne, Australia
,
D. J Castelan
1   Department of Medicine, Monash University, Prince Henry’s Hospital, and University of Melbourne Department of Medicine, St. Vincent’s Hospital, Melbourne, Australia
,
H. D Niall
1   Department of Medicine, Monash University, Prince Henry’s Hospital, and University of Melbourne Department of Medicine, St. Vincent’s Hospital, Melbourne, Australia
,
G. W Tregear
1   Department of Medicine, Monash University, Prince Henry’s Hospital, and University of Melbourne Department of Medicine, St. Vincent’s Hospital, Melbourne, Australia
› Author Affiliations
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Publication History

Publication Date:
27 June 2018 (online)

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Summary

The solid-phase radioimmunoassay method has been applied to the measurement of fibrinogen. The method is extremely sensitive, being able to detect fibrinogen concentrations as low as 10 ng/ml. The immunoreactivity of fibrinogen proteolysis products differs from that of native fibrinogen, early proteolysis products showing enhanced immunoreactivity which decreases progressively with further digestion.