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Thromb Haemost 1968; 20(01/02): 001-006
DOI: 10.1055/s-0038-1651243
Originalarbeiten – Original Articles – Travaux Originaux
Schattauer GmbH

Radioimmunoassay of Fibrinogen and Its Proteolysis Products

Authors

  • K. J Catt

    1   Department of Medicine, Monash University, Prince Henry’s Hospital, and University of Melbourne Department of Medicine, St. Vincent’s Hospital, Melbourne, Australia

  • J Hirsh

    1   Department of Medicine, Monash University, Prince Henry’s Hospital, and University of Melbourne Department of Medicine, St. Vincent’s Hospital, Melbourne, Australia

  • D. J Castelan

    1   Department of Medicine, Monash University, Prince Henry’s Hospital, and University of Melbourne Department of Medicine, St. Vincent’s Hospital, Melbourne, Australia

  • H. D Niall

    1   Department of Medicine, Monash University, Prince Henry’s Hospital, and University of Melbourne Department of Medicine, St. Vincent’s Hospital, Melbourne, Australia

  • G. W Tregear

    1   Department of Medicine, Monash University, Prince Henry’s Hospital, and University of Melbourne Department of Medicine, St. Vincent’s Hospital, Melbourne, Australia
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Publikationsdatum:
27. Juni 2018 (online)

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Summary

The solid-phase radioimmunoassay method has been applied to the measurement of fibrinogen. The method is extremely sensitive, being able to detect fibrinogen concentrations as low as 10 ng/ml. The immunoreactivity of fibrinogen proteolysis products differs from that of native fibrinogen, early proteolysis products showing enhanced immunoreactivity which decreases progressively with further digestion.