Download PDF
Thromb Haemost 1968; 19(01/02): 267-278
DOI: 10.1055/s-0038-1651205
Originalarbeiten – Original Articles – Travaux Originaux
Schattauer GmbH

The Influence of Fats on Blood Coagulation and Fibrinolysis

O. J. A Th. Meuwissen
1   Medical Department (Prof. Dr. F. L. J. Jordan and Prof. Dr. L. A. Hulst), University Hospital, Utrecht (Netherlands)
,
H Ch. Hart
1   Medical Department (Prof. Dr. F. L. J. Jordan and Prof. Dr. L. A. Hulst), University Hospital, Utrecht (Netherlands)
,
M. S. E van Hemel-Rupert Mrs.
1   Medical Department (Prof. Dr. F. L. J. Jordan and Prof. Dr. L. A. Hulst), University Hospital, Utrecht (Netherlands)
› Author Affiliations
Further Information

Publication History

Publication Date:
27 June 2018 (online)

    Permissions and Reprints

Summary

A review of experiments described in the literature discloses a lack of agreement about the influence of nutritional fats on blood coagulation and fibrinolysis. The numerous pertinent studies yielded contradictory results even if identical techniques were used.

In our investigation, 17 normal subjects were given a breakfast containing 57 g saturated fats and one containing 54 g unsaturated fats. Before and 3 hrs after ingestion of the high-fat meal, blood was collected for determination of blood coagulation and fibrinolysis. There was no demonstrable difference between the two blood samples in terms of recalcification time of platelet-rich plasma in siliconized glass, euglobulin activity, fibrinolytic activity measured by lysis of plasminogen-poor and plasminogen-rich standard clots labelled with I131-fibrinogen, “activated fibrinolysis” (measuring the antiplasmin concentration) and the susceptibility to fibrinolysis of fibrin clots prepared in a standardized manner from fasting and hyperlipaemic plasma samples.

In 6 normal subjects the experiments were expanded to encompass breakfasts with 118 saturated and 117 g unsaturated fats. After these high-fat meals, too, there was no demonstrable difference in recalcification time and in the various parameters of fibrinolysis.

In order to establish whether atherosclerotic patients would show a different reaction to high-fat meals, the experiments were carried out also in 17 patients suffering from severe generalized atherosclerosis. These patients were given a low-fat breakfast, one with 57 g saturated fats and one with 54 g unsaturated fats. In this group, too, there were no demonstrable differences between the preprandial and postprandial data on blood coagulation and various parameters of fibrinolysis.

 

  • References

  • 1 O’Brien J.B. Dietary fat and coronary disease. Brit. med. J 1957; II: 297
    PubMedGoogle Scholar
  • 2 MacFarlane R.G. The coagulant action of Russell's Viper Venom, the use of anti venom in defining its reaction with a serum factor. Brit. J. Haemat 1961; 7: 496
    CrossrefPubMedGoogle Scholar
  • 3 Duncan G.C, Waldron J.M. The effect of ingested fat on blood coagulation. Trans. Ass. Amer. Physicans. 1949; 62: 179
    PubMedGoogle Scholar
  • 4 Waldron J.M, Beidelman B, Duncan G. The local and systemic effects of cream on blood coagulation: a physiological basis for early feeding in gastro intestinal bleeding. Gastroenterology 1951; 17: 360
    PubMedGoogle Scholar
  • 5 Waldron J.M, Nichols W. Plasma lipids and whole blood clotting time. Amer. J. Physiol. 1952; 171: 776
    PubMedGoogle Scholar
  • 6 Fullerton H.W. Fat in the diet. Brit. med. J. 1955; 1: 663
    PubMedGoogle Scholar
  • 7 Poole J.C.F. The significance of chylomicra in blood coagulation. Brit. J. Haemat 1955; I: 229
    PubMedGoogle Scholar
  • 8 O’Brien J.R. Relation of blood coagulation to lipaemia. Lancet 1955; II: 690
    PubMedGoogle Scholar
  • 9 O’Brien J.R. Fat ingestion blood coagulation and atherosclerosis. Amer. J. med. Sci. 1957; 234: 373a
    PubMedGoogle Scholar
  • 10 Buzina R, Geys A. Blood coagulation after a fat meal. Circulation 1956; 41: 854
    PubMedGoogle Scholar
  • 11 Buzina R, Karvonen M, Roine P, Turpeinen O. Effect of changes in dietary fat on whole-blood coagulation-time in man. Lancet 1961; II: 287
    PubMedGoogle Scholar
  • 12 Kingsbury K.J, Morgan D.M. Effect of dietary triglycerides on recalcification time of plasma. Lancet 1957; II: 212
    PubMedGoogle Scholar
  • 13 Kommerell B, Berger H.D. Untersuchungen zur Gerinnungs-Aktivität und Fibrinolyse bei alimentärer Lipaemie. Klin. Wschr. 1959; 19: 1029
    PubMedGoogle Scholar
  • 14 Kommerell B. The significance of blood coagulation in atherosclerosis. J. Atheroscler. Res. 1962; 2: 233
    CrossrefPubMedGoogle Scholar
  • 15 Mustard J.F. Increased activity of the coagulation mechanism during alimentary lipaemia: its significance with regard to thrombosis and atherosclerosis. Canad. med. Ass. J 1957; 77: 308
    PubMedGoogle Scholar
  • 16 Mustard J.F, Murphy E.A. Effect of different dietary fats on blood coagulation, platelet economy and blood lipids. Brit. med. J 1962; I: 1651
    PubMedGoogle Scholar
  • 17 Pilkington T.B.E. The effect of fatty acids and detergents on the calcium clotting time of human plasma. Clin. Sci. 1957; 16: 269
    PubMedGoogle Scholar
  • 18 Bowsell H.C, Downie H.G, Mustard J.F. The experimental production of atherosclerosis in swine following the feeding of butter and margarine. Canad. med. Ass. J. 1958; 79: 647
    PubMedGoogle Scholar
  • 19 Lasch H.G. Alimentäre Fettzufuhr und Blutgerinnung. Med; Welt: 1961: 324
    Google Scholar
  • 20 Ollendorf F.P, Geill T, Astrup T, Lund E. The influence of diets containing certain animal and vegetable fats on the initiation of blood coagulation. Acta med. scand. 1961; 170: 3
    PubMedGoogle Scholar
  • 21 Tulloch J.A, Overman R.S, Wright I.S. Failure of ingestion of cream to affect blood coagulation. Amer. J. Med. 1953; 14: 674
    CrossrefPubMedGoogle Scholar
  • 22 Manning P.R, Walfort R.L. Lack of effect of fat ingestion on blood coagulation. Amer. J. med. Sci. 1954; 228: 652
    CrossrefPubMedGoogle Scholar
  • 23 Hall G.H. Reassesment of effect of fatty meals on blood coagulability. Brit. med. J. 1956; 2: 207
    CrossrefPubMedGoogle Scholar
  • 24 MacLagen N.F, Billimoria J.D. Food Lipids and blood coagulation. Lancet 1956; II: 235
    PubMedGoogle Scholar
  • 25 Merskey C, Nossel H.L. Blood coagulation after the ingestion of saturated and unsaturated Fats. Lancet 1957; I: 806
    PubMedGoogle Scholar
  • 26 Sohar E, Bosenthal M, Adlersberg D. Plasma lipids and coagulation of blood. Amer. J. clin. Path 1957; 27: 503
    PubMedGoogle Scholar
  • 27 Borrero J, Sheppard E, Wright I.S. Further experience with blood coagulation after fat meals and carbohydrate meals. Circulation 1958; 17: 936
    CrossrefPubMedGoogle Scholar
  • 28 O’Brien J.R. Blood coagulation before after a fatty meal. Lancet 1958; I: 410
    PubMedGoogle Scholar
  • 29 Nitzberg S.I, Beyman M.A, Goldstein R, Broger S. Studies of blood coagulation and fibrinolysis in patients with idiopathic hyperlipaemia and primary hyper cholesteremia before and after a fatty meal. Circulation 1959; 19: 676
    CrossrefPubMedGoogle Scholar
  • 30 Beyman M.A, Nitzberg S.I, Goldstein R, Nothman M, Proger S. The effect of long term feeding of Essential Fatty acids on blood coagulation and fibrinolysis. Amer. J. Med. 1960; 28: 884
    CrossrefPubMedGoogle Scholar
  • 31 Tompkins M.J, Dayton S, Pearce M.L. Effect of long term feeding of various fats on whole blood clotting times in man. J. Lab. Clin. Med. 1964; 64: 763
    PubMedGoogle Scholar
  • 32 Billimoria J.D, Irani V.J, MacLagan N.F. Phospholipid fractionation and blood clotting. J. Atheroscler. Res. 1965; 5: 90
    CrossrefPubMedGoogle Scholar
  • 33 Naimi S, Wilgram G.F, Nothman M.M, Proger S, Nutrikon J. Cardiovascular lesions, blood-lipids coagulation and fibrinolysis in butter induced obesity in the rat. J. Nutr. 1965; 86: 325
    CrossrefPubMedGoogle Scholar
  • 34 Greig H.B. Inhibition of fibrinolysis by alimentary lipaemia. Lancet 1956; II: 16
    PubMedGoogle Scholar
  • 35 Scott R.F, Thomas W.A. Methods for comparing effects of various fats on fibrinolysis.Proc. Soc. exp. Biol. (N. Y.) 1957; 96: 24
    PubMedGoogle Scholar
  • 36 Thomas W.A, Konikov N. R.M. O’ Neal, Kyu Taik Lee: Saturated versus unsaturated fats in experimental arteriosclerosis. A. M. A. Arch. Path 1957; 63: 571
    PubMedGoogle Scholar
  • 37 Billimoria J.D, Drysdale J, James D.C.O, MacLagan N.F. Determination of fibrinolytic activity of whole blood, with special reference to the effects of exercise and fat feeding. Lancet 1959; 11: 471
    PubMedGoogle Scholar
  • 38 Buckell M, Elliot F. Effect of butter lipaemia on the rate of clot lysis in normal males. Lancet 1959; I: 662
    PubMedGoogle Scholar
  • 39 Merigan T.C, Farquhar J.W, Williams J.H, Sokolow M. Effect of chylomicrons on the fibrinolytic activity of normal human plasma in vitro. Circulation 1959; 7: 205
    CrossrefPubMedGoogle Scholar
  • 40 Farquhar J.W, Merigan T.C, Sokolow M. Plasma fibrinolysis in man: the effect of chylomicrons derived from different dietary fats. J. exp. Med. 1961; 113: 587
    CrossrefPubMedGoogle Scholar
  • 41 Hougie C, Ayers F. Lipaemia and fibrinolytic potentiality. Lancet 1960; I: 186
    PubMedGoogle Scholar
  • 42 Fearnley G.R. Spontaneous Fibrinolysis. Amer. J. Cardiol 1960; 6: 371
    CrossrefPubMedGoogle Scholar
  • 43 Lackner H, Sougin-Mibashan R. Fibrinolysis and alimentary lipaemia in whites and Bantu's, their relationship and response to intravenous heparins. Thrombos. Diathes. haemorrh. (Stuttg.) 1964; 11: 108
    PubMedGoogle Scholar
  • 44 Moers A.M.J. De meting van de fibrinolyse. Academisch Proefschrift, Amsterdam. 1962
    Google Scholar
  • 45 Ogston D, Fullerton H.W. Effect of alimentary lipaemia on plasma fibrinolytic activity. Brit. med. J 1962; II: 1288
    PubMedGoogle Scholar
  • 46 Howell M. Effects of plasma lipids on fibrinolysis. Brit. med; Bull: 1964: 200 b
    Google Scholar
  • 47 Gajewski J. Effect of the ingestion of various fats on the fibrinolytic activity in normal subjects and patients. J. Atheroscler. Res 1961; I: 222
    PubMedGoogle Scholar
  • 48 Cliffton E.E, Cannamela D. Fibrinolytic and proteolytic activity of a human plasminogen, prepared from fraction III of human plasma. J. appl. Physiol. 1953; 6: 42
    CrossrefPubMedGoogle Scholar
  • 49 Konttinen Y. On the effect of alimentary lipaemia and a natural heparinoid on the fibrinolytic system of man. Scand. J. clin. Lab. Invest. 1962; 4: 87
    PubMedGoogle Scholar
  • 50 Paraskevas M, Nilsson I.M, Martinsson G. A model for determining serum inhibitors of plasminogen activation. Scand. J. clin. Lab. Invest. 1962; 14: 138
    CrossrefPubMedGoogle Scholar
  • 51 Merskey C, Mardus A.J. Lipids. Blood coagulation and Fibrinolysis. Ann. Rev. Med. 1963; 14: 323
    CrossrefPubMedGoogle Scholar
  • 52 Kowalski E, Kopec M, Niewiarowski S. An evaluation of the euglobulin method for the determination of fibrinolysis. J. clin. Path. 1959; 12: 215
    CrossrefPubMedGoogle Scholar
  • 53 McNicol G.P, Gale S.B, Douglas A.S. In: vitro and in vivo studies of a preparation of urokinase. Brit. Med. J 1963; I: 909
    PubMedGoogle Scholar
  • 54 Dudok de Wit, Chr., Fibrinolyse. Academisch proefschrift; Amsterdam: 1962
    Google Scholar
  • 55 Kwaan H.C, McFadzean A.J.S. Inhibition of fibrinolysis in vivo by feeding cholesterol. Nature (Lond.) 1957; 179: 260 a
    CrossrefPubMedGoogle Scholar
  • 56 Bang N.U, Cliffton E.E. The effect of Alimentary hyperlipaemia on thrombolysis in vivo. Thrombos. Diathes. haemorrh. (Stuttg.) 1960; 4: 149
    PubMedGoogle Scholar
  • 57 Fearnley G.R, Balmforth G, Fearnley E. Evidence of a diurnal fibrinolytic rhytm; with a simple method of measuring natural fibrinolysis. Clin. Sci. 1957; 16: 645
    PubMedGoogle Scholar
  • 58 Greig H.B.W, Runde I.A. Studies on the inhibition of fibrinolysis by lipids. Lancet 1957; II: 461
    PubMedGoogle Scholar
  • 59 Sarkar N. Reduced fibrinolytic activity of atherosclerotic sera caused by an increase in low density lipoproteins in blood. Nature 1961; 189: 929
    CrossrefPubMedGoogle Scholar
  • 60 Pappenhagen A.R, Koppel J.L, Olwin J.H. Observation on the in vitro effects of chylo-micra, low density lipoproteins, and phospholipids on human plasma euglobulin lysis. Thrombos. Diathes. haemorrh. (Stuttg.) 1963; 9: 164
    PubMedGoogle Scholar
  • 61 Skrzydlewski Z, Niewiarowski S, Skrzydlewski J. Inhibition of proteolytic enzymes by beta-lipoprotein. J. Atheroscler. Res. 1966; 6: 273
    CrossrefPubMedGoogle Scholar
  • 62 Clauss A. Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens. Acta haemat. (Basel) 1957; 17: 237
    CrossrefPubMedGoogle Scholar
  • 63 Meuwissen O.J.A.Th. De invloed van vetrijke maaltijden op de fibrinolyse. Academisch Proefschrift; Utrecht: 1966
    Google Scholar