Thromb Haemost 1989; 62(03): 856-860
DOI: 10.1055/s-0038-1651017
Original Article
Schattauer GmbH Stuttgart

Extrinsic Pathway Inhibitor in Elective Surgery: A Comparison with other Coagulation Inhibitors

P M Sandset
1   The Medical Department, Aker Hospital, University of Oslo, Oslo, Norway
,
H E Høgevold
2   The Department of Surgery, Ullevål Hospital, Oslo, Norway
,
T Lyberg
2   The Department of Surgery, Ullevål Hospital, Oslo, Norway
,
T R Andersson
1   The Medical Department, Aker Hospital, University of Oslo, Oslo, Norway
,
U Abildgaard
1   The Medical Department, Aker Hospital, University of Oslo, Oslo, Norway
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received 11. November 1988

Accepted after revision 24. Mai 1989

Publikationsdatum:
30. Juni 2018 (online)

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Summary

Extrinsic coagulation pathway inhibitor may be an important regulator of haemostasis to prevent thrombosis after tissue damage. The functional activity of this inhibitor was determined using a chromogenic substrate assay, and compared to the activities of anti thrombin, heparin cofactor II and protein C during the perioperative period of elective hip replacement (n = 28), cholecystectomy (n = 11), and vascular surgery (n = 5). Peroperatively, all the inhibitors decreased rather similarly and to the same degree as the decrease in albumin concentration. The decreases during hip surgery were about 2-fold the decreases observed during cholecystectomy. A significant peroperative increase in extrinsic pathway inhibitor activity was observed in vascular surgery, probably due to a bolus injection of heparin. Antithrombin, heparin cofactor II and protein C levels normalized on days 3-5 postoperatively in all three patient groups. Sustained low levels of extrinsic pathway inhibitor were observed on postoperative days 1 to 7 in hip surgery patients. Apparently, extrinsic pathway inhibitor is not an acute phase reactant. In uncomplicated surgery, the decreases of the coagulation inhibitor levels are mainly due to hemodilution.