Resistance to Activated Protein C (APCR): Reference Values of APC-Ratios for Children

M M Uttenreuther-Fischer; S Ziemer; G Gaedicke

doi:10.1055/s-0038-1650665

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1996; 76(05): 813-814
DOI: 10.1055/s-0038-1650665

Letters to the Editor

Schattauer GmbH Stuttgart

Resistance to Activated Protein C (APCR): Reference Values of APC-Ratios for Children

M M Uttenreuther-Fischer

¹The Department of Pediatrics, Humboldt University, Augustenburger Platz 1, D-13358 Berlin, Germany

²The laboratory for Pediatric Molecular Biology, ZiegelstraBe 5-9 (II. OG), D-10117 Berlin (corresponding author), Germany

,

S Ziemer

³The institute for Pathological and Clinical Biochemistry, Humboldt University, SchumannstraBe 20-21, D-10098 Berlin, Germany

,

G Gaedicke

¹The Department of Pediatrics, Humboldt University, Augustenburger Platz 1, D-13358 Berlin, Germany

²The laboratory for Pediatric Molecular Biology, ZiegelstraBe 5-9 (II. OG), D-10117 Berlin (corresponding author), Germany

› Author Affiliations

Abstract

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References

References
1 Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-67
2 Dahlbäck B. Inherited thrombophilia: Resistance to activated protein c as a pathogenic factor of venous thromboembolism. Blood 1995; 85: 607-614
3 Dahlbäck B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 1993; 90: 1004-1008
4 Nowak-Gottl U, Koch HG, Aschka I, Kohlhase B, Vielhaber H, Kurlemann G, Oleszcuk-Raschke K, Kehl HG, Jürgens H, Schneppenheim R. Resis-tence to activated protein c (APCR) in children with venous or arterial thromboembolism. Br J Haematol 1996; 92: 992-998
5 Klinge J, Ries M, Rauch R, Kraus M. Resistenz gegen aktiviertes Protein c in Kindesalter - Bestimmung von Normwerten mit einem neuen APC-Sensitivitatstest. Monatsschr Kinderheilkd 1995; 143 (Suppl. 03) S272-P649 (Abstract).
6 Andrew M, Schmidt B. Hemorrhagic and thrombotic complications in children. In: Hemostasis and thrombosis: Basic principles and clinical practice Colman RW, Hirsh J, Marder VJ, Salzman EW. (eds). 3rd Ed. J. B. Lippin-cott Company; Philadelphia: 1994: 989-1022
7 Otting U, Hellmann C, Uttenreuther-Fischer M, Ziemer S, Sprenger R, Gaedicke G. Protein C-, Protein S-Aktivitat und APC-Widerstandsindex bei Kindern mit portaler Hypertension. Monatsschr Kinderheilkd 1995; 143 (Suppl. 03) S273-P653 (Abstract)
8 Svensson PJ, Dahlbäck B. Resistance to activated protein C as a basis for venous thrombosis. N Engl J Med 1994; 330: 517-522
9 Nowak-Göttl U, Kohlhase B, Vielhaber H, Aschka I, Schneppenheim R, Jürgens H. APC resistance in neonates and infants: adjustment of the APTT-based method. Thromb Res 1996; 81: 665-670
10 Nori K, Hillman-Wiseman C, Lusher J. Activated protein C (APC) resistance: effect of sex, race and age. Blood 1994; 84: 83a-322 (Abstract)