Thromb Haemost 1996; 76(03): 344-346
DOI: 10.1055/s-0038-1650581
Original Article
Schattauer GmbH Stuttgart

Cyclosporine Therapy for Acquired Factor VIII Inhibitor in a Patient with Systemic Lupus Erythematosus

S Schulman
1   The Institute of Thrombosis and Hemostasis and National Hemophilia Center, Department of Hematology, Tel-Hashomer, Israel
,
P Langevitz
Department of Internal Medicine, The Chaim Sheba Medical Center, Tel-Hashomer, Israel
,
A Livneh
Department of Internal Medicine, The Chaim Sheba Medical Center, Tel-Hashomer, Israel
,
U Martinowitz
1   The Institute of Thrombosis and Hemostasis and National Hemophilia Center, Department of Hematology, Tel-Hashomer, Israel
,
U Seligsohn
1   The Institute of Thrombosis and Hemostasis and National Hemophilia Center, Department of Hematology, Tel-Hashomer, Israel
,
D Varon
1   The Institute of Thrombosis and Hemostasis and National Hemophilia Center, Department of Hematology, Tel-Hashomer, Israel
› Author Affiliations
Further Information

Publication History

Received 12 March 1996

Accepted after revision 22 May 1996

Publication Date:
10 July 2018 (online)

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Summary

The case of a 27-year-old woman with systemic lupus erythematosus and development of an autoantibody against factor VIII during an exacerbation of her underlying disorder is described. Attempts to eliminate the antibody with high dose gammaglobulin and repeated courses of cyclophosphamide failed, whereafter she received cyclosporine in increasing doses. When therapeutic serum levels of cyclosporine were achieved (150-350 ng/ml) the inhibitor rapidly decreased and disappeared with a concomitant normalization of the factor VIII levels. Treatment with cyclosporine was subsequently reduced and discontinued after one year, and at present no inhibitor is detectable. In view of the successful results with cyclosporine treatment in 4 of 6 previous cases and in all 3 previous cases with autoimmune disorders, this regimen should be evaluated in a systematic manner as a potential first line drug in patients with acquired hemophilia and an underlying autoimmune disorder.