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Thromb Haemost 1996; 75(06): 933-938
DOI: 10.1055/s-0038-1650397
Original Article
Schattauer GmbH Stuttgart

Localization of Fibrinolytic Activators and Inhibitors in Normal and Atherosclerotic Vessels

Marten Fålkenberg
1   The Department of Surgery, Östra and Sahlgrenska University Hospital, Gothemburg, Sweden
,
Johan Tjärnstrom
1   The Department of Surgery, Östra and Sahlgrenska University Hospital, Gothemburg, Sweden
,
Per Örtenwall
1   The Department of Surgery, Östra and Sahlgrenska University Hospital, Gothemburg, Sweden
,
Michael Olausson
2   Sahlgrenska University Hospital, Gothemburg, Sweden
,
Bo Risberg
3   Malmö University Hospital, Malmö, Sweden
› Author Affiliations
Further Information

Publication History

Received 21 November 1995

Accepted after resubmission 06 March 1996

Publication Date:
11 July 2018 (online)

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Summary

Local fibrinolytic changes in atherosclerotic arteries have been suggested to influence plaque growth and promote mural thrombosis on ruptured or ulcerated plaques. Increased levels of plasminogen activator inhibitor (PAI-1) have been found in atherosclerotic arteries. In this study tissue plasminogen activator (t-PA), urokinase-type plasminogen activator (u-PA) and PAI-1 were localized in arterial biopsies of healthy and atherosclerotic vessels by immunohistochemis-try. The expression of fibrinolytic regulators was related to the distribution of endothelial cells (EC) and macrophages. Results: t-PA was expressed in vasa vasorum. PAI-1 was positive in endothelial cells, in the media and in the adventitia. Increased expression of t-PA, u-PA and PAI-1 was found in atherosclerotic vessels. t-PA, u-PA, PAI-1 and macrophages were co-localized in plaques. These results support the concept that macrophages can be important in the local regulation of fibrinolysis in atherosclerotic vessels.

 

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