Thromb Haemost 1996; 75(02): 233-238
DOI: 10.1055/s-0038-1650250
Original Article
Schattauer GmbH Stuttgart

Low Molecular Weight Heparin and Compression Stockings in the Prevention of Venous Thromboembolism in Neurosurgery

M T Nurmohamed
1  The Center for Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Academic Medical Center, Amsterdam
,
A M van Riel
2  St. Elisabeth Hospital, Tilburg
,
C M A Henkens
3  Center for Hemostasis, Thrombosis and Rheology, University Hospital Groningen, Groningen, The Netherlands
,
M M W Koopman
1  The Center for Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Academic Medical Center, Amsterdam
,
G T H Que
3  Center for Hemostasis, Thrombosis and Rheology, University Hospital Groningen, Groningen, The Netherlands
,
P D’Azemar
4  Sanofi Recherche SA, Paris, France
,
H R Büller
1  The Center for Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Academic Medical Center, Amsterdam
,
J W ten Cate
1  The Center for Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Academic Medical Center, Amsterdam
,
J A Hoek
5  Sanofi-Winthrop VOF, Maassluis, The Netherlands
,
J van der Meer
3  Center for Hemostasis, Thrombosis and Rheology, University Hospital Groningen, Groningen, The Netherlands
,
C van der Heul
2  St. Elisabeth Hospital, Tilburg
,
A G G Turpie
6  Hamilton Civic Hospitals Research Center, McMaster University, Hamilton, Canada
,
S Haley
6  Hamilton Civic Hospitals Research Center, McMaster University, Hamilton, Canada
,
J Sicurella
6  Hamilton Civic Hospitals Research Center, McMaster University, Hamilton, Canada
,
M Gent
6  Hamilton Civic Hospitals Research Center, McMaster University, Hamilton, Canada
› Author Affiliations
Further Information

Publication History

Received: 18 August 1995

Accepted after revision06 November 1995

Publication Date:
31 August 2018 (online)

Summary

Perioperative anticoagulant prophylaxis for postoperative venous thromboembolism (VTE) in neurosurgical patients has not gained wide acceptance due to the fear of intracranial bleeding. Physical methods give a worthwhile reduction of postoperative VTE but there still remains a substantial residual incidence. In other clinical indications, low molecular weight heparins have proven to be effective for prophylaxis of VTE when administered postoperatively, with the advantage of no bleeding enhancement during surgery.

Therefore, we performed a multicentre, randomized, double-blind trial in neurosurgical patients to investigate the efficacy and safety of adding a low molecular weight heparin (LMWH), nadroparin, initiated postoperatively, to graduated compression stockings in the prevention of VTE. Deep-vein thrombosis was detected by mandatory venography. Bleeding was determined according to pre-defined objective criteria for major and minor episodes.

An adequate bilateral venogram was obtained in 166 of 241 LMWH patients (68.9%) and 179 of 244 control patients (73.4%). A total of 31 of 166 LMWH patients (18.7%) and 47 of 179 control patients (26.3%) had VTE up to Day 10 postoperatively (p = 0.047). The relative risk reduction (RRR) was 28.9%. The rates for proximal deep-vein thrombosis/pulmonary embolism were 6.9% and 11.5% for the two groups, respectively (RRR: 40.2%; p = 0.065).

Secondary analyses involved all VTE up to day 56 post-surgery which was detected in 33 patients of 241 in the LMWH group (13.7%) and 51 of 244 control patients (20.9%; RRR 34.5%; p = 0.018). The corresponding percentages for proximal deep-vein thrombosis/pulmonary embolism were 5.8% and 10.2% for the two groups, respectively, giving a RRR of 43.3%; p = 0.036. Major bleeding complications, during the treatment period, occurred in six low molecular weight heparin treated patients (2.5%) and in two control patients (0.8%); p = 0.087.

A higher mortality was observed in the low molecular weight heparin group over the 56-day follow-up period (22 versus 10; p = 0.026). However, none of these deaths was judged by a blinded adjudication committee to be related to the study drug.

In conclusion, this study demonstrates that the low molecular weight heparin, nadroparin, added to graduated compression stockings results in a clinically significant decrease in VTE without inducing any significant increase of major bleeding.