Effect of Local Urokinase on Arterial Occlusion of Lower Limbs

Summary

Sixty nine patients were treated with local intra-arterial urokinase (37,500 U/CTA. hr^-1) for recent severe ischemia of lower limbs: 27 (40%) ultimately required amputation. The difference of amputation rate between the groups with and without thrombolysis was not significant (33% v. 42%). A biological study in 6 patients showed that local arterial plasminemia occurred in only 1 patient. Local urokinase does not strongly stimulate “endogenous” thrombolysis and enhances “exogenous” thrombolysis only very inconstantly. A better adaptation of urokinase dosage or the use of an agent with a higher affinity for fibrin might improve the efficiency of local thrombolytic therapy.

Keywords

Thrombolysis - Urokinase - Local urokinase - Lower limbs ischemia

• References

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