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Thromb Haemost 1981; 45(02): 142-145
DOI: 10.1055/s-0038-1650151
Original Article
Schattauer GmbH Stuttgart

Lithium Inhibits Adenylate Cyclase of Human Platelets

Leon Imandt
The Division of Haematology, Department of Internal Medicine, University of Nijmegen, Nijmegen, The Netherlands
,
Dorien Tijhuis
The Division of Haematology, Department of Internal Medicine, University of Nijmegen, Nijmegen, The Netherlands
,
Hans Wessels
The Division of Haematology, Department of Internal Medicine, University of Nijmegen, Nijmegen, The Netherlands
,
Clemens Haanen
The Division of Haematology, Department of Internal Medicine, University of Nijmegen, Nijmegen, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 22 September 1980

Accepted 20 January 1981

Publication Date:
05 July 2018 (online)

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Summary

The ADP-induced aggregation of human platelets is markedly increased after preincubation with lithiumchloride, whereas lithium has the opposite effect on rabbit platelets. Since this phenomenon might be related to cAMP metabolism, the influence of lithium on total cAMP content and adenylate cyclase activity was investigated. Lithium does not significantly change the total cAMP content of human platelets neither during incubation nor during ADP-induced aggregation. Basal adenylate cyclase activity, however, was slightly inhibited by lithium in human platelets. The inhibition of adenylate cyclase by ADP appeared to be enhanced by lithium. Prostacyclin induced stimulation of adenylate cyclase is counteracted by this ion.

In rabbit platelets the prostacyclin stimulated adenylate cyclase activity is not affected by lithium.

These data suggest that a correlation exists between the influence of lithium on the aggregation of human and rabbit platelets and the sensitivity of their adenylate cyclase for this ion.

Keywords

Platelets - Lithium - Adenylate cyclase - Aggregation
 

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