Catabolism of Human Fibrinogen Fragment D in Normal Subjects and Patients with Liver Cirrhosis

Nicole Ardaillou; Jeannine Yvart; Philippe Le Bras; Marie-José Larrieu

doi:10.1055/s-0038-1650106

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1980; 44(03): 146-149
DOI: 10.1055/s-0038-1650106

Original Article

Schattauer GmbH Stuttgart

Catabolism of Human Fibrinogen Fragment D in Normal Subjects and Patients with Liver Cirrhosis

Nicole Ardaillou

The Department of Coagulation INSERM U. 143, Institut de Pathologie Cellulaire and from the Department of Nuclear Medicine and of Internal Medicine, Hôpital Bicêtre, Kremlin-Bicêtre, France

,

Jeannine Yvart

The Department of Coagulation INSERM U. 143, Institut de Pathologie Cellulaire and from the Department of Nuclear Medicine and of Internal Medicine, Hôpital Bicêtre, Kremlin-Bicêtre, France

,

Philippe Le Bras

The Department of Coagulation INSERM U. 143, Institut de Pathologie Cellulaire and from the Department of Nuclear Medicine and of Internal Medicine, Hôpital Bicêtre, Kremlin-Bicêtre, France

,

Marie-José Larrieu

The Department of Coagulation INSERM U. 143, Institut de Pathologie Cellulaire and from the Department of Nuclear Medicine and of Internal Medicine, Hôpital Bicêtre, Kremlin-Bicêtre, France

› Author Affiliations

Abstract

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Summary

The catabolism of human fragment D, (FgD), obtained by plasmin digestion of fibrinogen has been investigated in normal subjects and patients with liver cirrhosis and the results compared with those obtained for fibrinogen (Fg). Fg was labelled with I-125 and Fg D with I-131 using the chloramine T method. The plasma disappearance curves of both labelled proteins fitted a two exponential curve. In controls the plasma clearance rate of Fg D was greater than that of Fg as shown by the marked difference between the half-lives of these two tracers: 8,9 and 83,5 hours for Fg D and Fg respectively. The fractional catabolic rate of Fg D was 3.38 times the plasma pool per day. In nine patients with liver cirrhosis, catabolism of Fg was not modified. In contrast, catabolism of Fg D was significantly reduced with a half life of 13.0 hours and a low fractional catabolic rate. These results suggest the role of the liver in the catabolism of Fg D in man.

Key words

Catabolism - Fibrinogen degradation products - Fragment D - Liver cirrhosis

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References

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