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Thromb Haemost 1980; 44(03): 143-145
DOI: 10.1055/s-0038-1650105
Original Article
Schattauer GmbH Stuttgart

Effects of Halothane on Platelet Function

J Dalsgaard-Nielsen
The Coagulation Laboratory, Kommunehospitalet, Copenhagen, Denmark
,
J Gormsen
The Coagulation Laboratory, Kommunehospitalet, Copenhagen, Denmark
› Author Affiliations
Further Information

Publication History

Received 30 June 1980

Accepted 25 September 1980

Publication Date:
13 July 2018 (online)

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Summary

Human platelets in platelet rich plasma (PRP) incubated at 37° C with 0.3–2% halothane for 5–10 min lost the ability to aggregate with ADP, epinephrine and collagen.

At the same time uptake and release of 14C-serotonin was inhibited. When halothane supply was removed, platelet functions rapidly returned to normal. However, after high concentrations of halothane, the inhibition of platelet aggregation was irreversible or only partially reversible.

The results suggest that halothane anaesthesia produces a transient impairment of platelet function.

Key words

Halothane - (Inhibition of) Platelet aggregation - Serotonin uptake - Serotonin release
 

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