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Thromb Haemost 1980; 44(03): 130-134
DOI: 10.1055/s-0038-1650102
Original Article
Schattauer GmbH Stuttgart

Soluble Fibrin Complexes and Fibrinogen Heterogeneity in Diabetes mellitus

E B Tsianos
The Professorial Unit, Evangelismos Hospital, Athens, Greece
,
N E Stathakis
The Professorial Unit, Evangelismos Hospital, Athens, Greece
› Author Affiliations
Further Information

Publication History

Received 12 November 1979

Accepted 23 September 1980

Publication Date:
13 July 2018 (online)

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Summary

The presence of soluble fibrin complexes (SFC) measured by gel filtration of plasma on 4% agarose columns, fibrinogen heterogeneity on 3.5% SDS-polyacrylamide gels and the concentrations of several plasma proteins were evaluated in 39 patients with diabetes mellitus (DM) and 19 matched control subjects. A small but significant increase of SFC was found in DM (p<0.01). On individual basis 51.2% of the patients had increased SFC (>M + 2 SD of the controls). Polyacrylamide gel electrophoresis of the SFC showed no evidence of cross-linking or proteolysis. Plasma clots formed in the presence of EDTA and trasylol were analysed in SDS-polyacrylamide gels in a normal and two lower molecular weight fibrin bands (band I, II, III). The percentage of band I fibrinogen was in diabetics (65.3 ± 4.7%) lower than that of the controls (71.8 ± 4.5%) (p < 0.01). Fibrinogen levels, antithrombin III, α1-antitrypsin, α2-macroglobulin and plasminogen were significantly increased in DM. We suggest that in DM there is an enhancement of intravascular fibrin formation and accelerated fibrinogen degradation to lower molecular weight forms.

Key words

Diabetes mellitus - Soluble fibrin complexes - Fibrinogen heterogeneity
 

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