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Thromb Haemost 1980; 44(01): 039-042
DOI: 10.1055/s-0038-1650077
Original Article
Schattauer GmbH Stuttgart

A Survey of the Effectiveness of Prothrombin Complex Concentrates in Controlling Hemorrhage in Patients with Hemophilia and Anti-Factor VIII Antibodies

Philip M Blatt
The Departments of Medicine and Pathology, University of North Carolina, Chapel Hill, North Carolina, U.S.A. American Red Cross Blood Services Laboratories, Bethesda, Maryland, U.S.A.
,
Doris Ménaché
The Departments of Medicine and Pathology, University of North Carolina, Chapel Hill, North Carolina, U.S.A. American Red Cross Blood Services Laboratories, Bethesda, Maryland, U.S.A.
,
Harold R Roberts
The Departments of Medicine and Pathology, University of North Carolina, Chapel Hill, North Carolina, U.S.A. American Red Cross Blood Services Laboratories, Bethesda, Maryland, U.S.A.
› Author Affiliations
Further Information

Publication History

Received 25 October 1979

Accepted 07 July 1980

Publication Date:
13 July 2018 (online)

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Summary

The treatment of patients with hemophilia A and anti-Factor VIII antibodies is difficult. Between July 1977 and June 1978, a survey was carried out by an ad hoc working party of the subcommittee on Factor IX concentrates of the International Committee on Thrombosis and Hemostasis to assess the effectiveness of Prothrombin Complex Concentrates in controlling hemorrhage in these patients. The results are presented in this paper and, although subjective, support the view that these concentrates are not as effective in patients with inhibitors as Factor VIII concentrates are in patients without inhibitors.

 

  • References

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