Thromb Haemost 1980; 43(03): 208-210
DOI: 10.1055/s-0038-1650053
Original Article
Schattauer GmbH Stuttgart

Platelet Dense Bodies Loaded with Mepacrine Study in Chronic Idiopathic Thrombocytopenic Purpura (ITP)

P Hourdille
The Laboratoire d'Hémobiologie, Hôpital Cardiologique de Bordeaux, France
,
P Bernard
The Laboratoire d'Hémobiologie, Hôpital Cardiologique de Bordeaux, France
,
J Reiffers
The Laboratoire d'Hémobiologie, Hôpital Cardiologique de Bordeaux, France
,
A Broustet
The Laboratoire d'Hémobiologie, Hôpital Cardiologique de Bordeaux, France
,
M R Boisseau
The Laboratoire d'Hémobiologie, Hôpital Cardiologique de Bordeaux, France
› Author Affiliations
Further Information

Publication History

Received 07 January 1980

Accepted 03 June 1980

Publication Date:
13 July 2018 (online)

Summary

In 22 cases of chronic ITP, the platelet 5-HT storage organelles were counted by examination of platelets loaded with mepacrine and correlated with the size and volume of the platelets. Statistical analysis showed that the mean volume and the number of granules increased in ITP without increase in the mean number of granules per unit volume. A strong correlation was found between platelet long diameter and number of dense bodies in controls (44 healthy subjects) (r = 0.94; y = 2.826 × – 0.699) and in ITP (r = 0.92; y = 2.587 × + 0.06). This study demonstrated in chronic ITP the presence both of platelets without granules and others rich in granules. These anomalies were present no matter what the count of platelets and did not change the mean values for granules and for ADP in most cases. Most platelets remain morphologically normal.