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Thromb Haemost 1980; 43(03): 194-197
DOI: 10.1055/s-0038-1650050
Original Article
Schattauer GmbH Stuttgart

An Attempt at Predicting Postoperative Deep Vein Thrombosis by Preoperative Coagulation Studies in Patients Undergoing Total Hip Replacement

Dennis W T Nilsen
The Oslo Emergency Medical Centre, University Hospital of Ullevål, Oslo and State Laboratory of Microbiology, Department of Immunohaematology and Blood Transfusion, Lillehammer, Norway
,
Miladin Jeremic
The Oslo Emergency Medical Centre, University Hospital of Ullevål, Oslo and State Laboratory of Microbiology, Department of Immunohaematology and Blood Transfusion, Lillehammer, Norway
,
Odd K Weisert
The Oslo Emergency Medical Centre, University Hospital of Ullevål, Oslo and State Laboratory of Microbiology, Department of Immunohaematology and Blood Transfusion, Lillehammer, Norway
› Author Affiliations
Further Information

Publication History

Received 20 March 1980

Accepted 21 May 1980

Publication Date:
13 July 2018 (online)

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Summary

Preoperative levels of fibrinogen, factors V, VII, VIII and antithrombin III were measured in 25 consecutive patients undergoing total hip replacement. Deep vein thrombosis (D.V.T.) was detected by fibrinogen-uptake test in 60% of the patients. The preoperative fibrinogen level was significantly higher (p < 0.05), and serum antithrombin III was markedly lower (p ≦ 0.1) in patients with postoperative D.V.T. The quotient of fibrinogen to serum antithrombin III was significantly higher (p < 0.01) in patients with D.V.T. This quotient may serve as an additional parameter to other clinical and laboratory tests in prediction of postoperative D.V.T. following hip surgery.

Keywords

Preoperative coagulation factors - Postoperative thrombosis in hip surgery
 

  • References

  • 1 Stamatakis JD, Sagar S, Maffei FH, Lawrence D, Kakkar VV. Femoral vein thrombosis and total hip replacement arthroplasty. Brit J Surg 1976; 63: 668-669
    PubMedGoogle Scholar
  • 2 Nillius AS, Nylander G. Deep vein thrombosis after total hip replacement: a clinical and phlebographic study. Brit J Surg 1979; 66: 324-326
    CrossrefPubMedGoogle Scholar
  • 3 Clayton JK, Anderson JA, McNicol GP. Preoperative prediction of postoperative deep vein thrombosis. Brit Med J 1976; 2: 910-912
    CrossrefPubMedGoogle Scholar
  • 4 Rakoczi I, Chamone D, Collen D, Verstraete M. Prediction of postoperative leg-vein thrombosis in gynaecological patients. Lancet 1978; 1: 509-510
    PubMedGoogle Scholar
  • 5 Kakkar VV. The diagnosis of deep vein thrombosis using the 125I Fibrinogen test. Arch Surg 1972; 104: 152-159
    CrossrefPubMedGoogle Scholar
  • 6 Weisert O, Jeremic M. Plasma fibrinogen levels in 1,016 regular blood donors. I. The influence of age and sex on mean values and percentiles. Vox Sang. 1974; 27: 176-185
    CrossrefPubMedGoogle Scholar
  • 7 Weisert O, Jeremic M. Preservation of coagulation factors V and VIII during collection and subsequent storage of bank blood in ACD-A and CPD solutions. Vox Sang. 1973; 24: 126-133
    CrossrefPubMedGoogle Scholar
  • 8 Sagar S, Nairn D, Stamatakis JD, Maffei FH, Higgins AF, Thomas DP, Kakkar VV. Efficacy of low-dose heparin in prevention of extensive deep-vein thrombosis in patients undergoing total-hip replacement. Lancet 1976; 1: 1151-1154
    PubMedGoogle Scholar
  • 9 Hume M. The relation of "hypercoagulability" to thrombosis. Monogr Surg Sci 1965; 2: 133-157
    PubMedGoogle Scholar
  • 10 Vessey MP. The epidemiology of venous thromboembolism. In: Poller L. Recent advances in thrombosis . Churchill Livingstone, Edinburgh - London: 1973. pp. 39-58
    Google Scholar
  • 11 Meade TW, North WR S. Population-based distribution of haemostatic variables. Brit Med Bull 1977; 33: 283-288
    CrossrefPubMedGoogle Scholar
  • 12 Gedde-Dahl TW, Jeremic M, Weisert O. Factor V (proaccelerin) concentration in 1016 blood donors. The effects of age, sex, and ABO blood groups. Scand J clin Lab Invest 1975; 35: 25-30
    CrossrefPubMedGoogle Scholar
  • 13 Brozović M, Chakrabarti R, Stirling Y, Fenton S, North WR S, Meade TW. Factor V in an industrial population. Brit J Haemat 1976; 33: 543-550
    CrossrefPubMedGoogle Scholar
  • 14 Brozović M, Stirling Y, Harricks C, North WR S, Meade TW. Factor VII in an industrial population. Brit J Haemat 1974; 28: 381-391
    CrossrefPubMedGoogle Scholar
  • 15 Jeremic M, Weisert O, Gedde-Dahl TW. Factor VIII (AHG) levels in 1016 regular blood donors. The effects of age, sex and ABO blood groups. Scand J clin Lab Invest 1976; 36: 461-466
    CrossrefPubMedGoogle Scholar
  • 16 Penick GD. Blood states that predispose to thrombosis. In: Sherry S, Brinkhouse KM, Genton E, Stengle JM. Thrombosis . National Academy of Sciences, Washington, D. C.: 1969. pp. 553-565
    Google Scholar
  • 17 Abildgaard U. Binding of thrombin to antithrombin III. Scand J clin Lab Invest 1969; 24: 23-27
    CrossrefPubMedGoogle Scholar
  • 18 Biggs R, Denson KW E, Akman N, Borret R, Hadden M. Antithrombin III, antifactor Xa and heparin. Brit J Haemat 1970; 19: 283-305
    CrossrefPubMedGoogle Scholar
  • 19 Egeberg O. Inherited antithrombin deficiency causing thrombophilia. Thrombos Diathes haemorrh 1965; 13: 516-530
    PubMedGoogle Scholar
  • 20 von der Meer J, Stoepman-van Dalen EA, Jansen JM S. Antithrombin III deficiency in a Dutch family. J Clin Path 1973; 26: 532-538
    CrossrefPubMedGoogle Scholar
  • 21 von Kaulla E, von Kaulla KN. Deficiency of antithrombin III activity associated with hereditary thrombosis tendency. J Med 1972; 3: 349-358
    PubMedGoogle Scholar
  • 22 Marciniak E, Farley CH, DeSimone PA. Familial thrombosis due to antithrombin III deficiency. Blood 1974; 43: 219-231
    PubMedGoogle Scholar
  • 23 Sagar S, Stamatakis JD, Thomas DP, Kakkar VV. Oral contraceptives, antithrombin III activity, and postoperative deep-vein thrombosis. Lancet 1976; 1: 509-517
    PubMedGoogle Scholar
  • 24 Blombäck M, Blombäck B, Olsson P, Svendsen L. The assay of antithrombin using a synthetic chromogemc substrate for thrombin. Thromb Res 1974; 5: 621-632
    CrossrefPubMedGoogle Scholar
  • 25 Ødegaard OR, Lie M, Abildgaard U. Heparin cofactor activity measured with an amidolytic method. Thromb Res 1975; 6: 287-294
    CrossrefPubMedGoogle Scholar
  • 26 von Kaulla E, von Kaulla KN. Antithrombin III and diseases. Amer J Clin Path 1967; 48: 69-80
    PubMedGoogle Scholar
  • 27 Innerfield I, Goldfischer JD, Reicherreise H, Greenberg J. Serum antithrombin in coronary-artery disease. Amer J Clin Path 1976; 65: 64-68
    PubMedGoogle Scholar
  • 28 Innerfield I. Acquired thrombophilia: A hitherto unrecognized pro-coagulant-antithrombin imbalance. Scand J Haemat 1976; 16: 202-208
    PubMedGoogle Scholar