Thromb Haemost 1980; 43(02): 118-123
DOI: 10.1055/s-0038-1650030
Original Article
Schattauer GmbH Stuttgart

Anticoagulant and Antithrombotic Action of Novel Specific Inhibitors of Thrombin

J Hauptmann
The Institute of Pharmacology and Toxicology, Medical Academy Erfurt, Erfurt, GDR
,
B Kaiser
The Institute of Pharmacology and Toxicology, Medical Academy Erfurt, Erfurt, GDR
,
F Markwardt
The Institute of Pharmacology and Toxicology, Medical Academy Erfurt, Erfurt, GDR
,
G Nowak
The Institute of Pharmacology and Toxicology, Medical Academy Erfurt, Erfurt, GDR
› Institutsangaben
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Publikationsverlauf

Received 17. Dezember 1979

Accepted 18. Februar 1980

Publikationsdatum:
13. Juli 2018 (online)

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Summary

A series of new specific inhibitors of thrombin, cyclic amides of Nα-arylsulfonyl-amidinophenylalanine, was studied for anticoagulant action in vitro and in vivo. The inhibitors showed strong anticoagulant effects in vitro. The time course of the anticoagulant effect of the inhibitors in rabbits and rats was monitored using plasma thrombin time determinations. In rats, the inhibitors prevented the formation of experimental venous thrombi and of thrombin-induced microthrombosis. The new derivatives of benz-amidine presented may be useful as immediately acting anticoagulants.