The Activity of Heparin in the Presence and Absence of Ca²⁺ Ions; why the Anti-Xa Activity of LMW Heparins Is about two Times Overestimated

• References

• 1 Béguin S, Dol F, Hemker HC. The consumption of antithrombin III and heparin during the clotting process, its influence on the thrombin decay constant. Thromb Haemostas 1992; 68: 136-142
• 2 Schoen P, Hemker HC, Lindhout T. Ratios of anti-factor Xa to antithrombin activities in recalcified human plasma. Br J Haematol 1992; 81: 255-262
• 3 Barrowcliffe T, Le Shirley Y. The effect of CaCl₂ on anti-Xa activity of heparin and its molecular weight fractions. Thromb Haemostas 1989; 62: 950-954
• 4 Barrowcliffe TW, Curtis AD, Johnson EA, Thomas DP. An international Standard for low molecular weight heparin. Thromb Haemostas 1988; 60: 1-7
• 5 Hemker HC, Béguin S, Bendetowicz AV, Wielders S. The determination of the levels of unfractionated and low molecular weight heparins in plasma. Their effect on thrombin mediated feedback reactions in vivo. Preliminary results on samples after subcutaneous injection. Haemostasis 1991; 21: 258-272
• 6 Hemker HC. A Standard for low molecular weight heparin?. Haemostasis 1989; 19: 1-4