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Thromb Haemost 1966; 15(03/04): 428-435
DOI: 10.1055/s-0038-1649444
DOI: 10.1055/s-0038-1649444
Originalarbeiten — Original Articles — Travaux Originaux
The Clot-Promoting Effect of Adenosine-5’- Diphosphate (ADP). I. Mechanisms of Action
Further Information
Publication History
Publication Date:
27 June 2018 (online)
Summary
1. ADP accelerates blood coagulation by at least two mechanisms. One is by causing release of coagulant phospholipids from platelets. The other is by activation of a plasma coagulation factor whose action is early in thromboplastin generation.
2. Possible mechanisms of ADP’s effect on blood coagulation are discussed.
3. These findings suggest that ADP may play a more significant role in the mechanisms of hemostasis and in the pathophysiology of thrombosis than has heretofore been supposed.
* Present address: Hospital de Enfermedades de la Nutricion, Mexico City, Mexico.
** Present address: Mayo Clinic, Rochester, Minn., U.S.A.
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