Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1966; 15(01/02): 238-251DOI: 10.1055/s-0038-1649425 Originalarbeiten — Original Articles — Travaux Originaux Schattauer GmbH The Monoiodoacetate (MIA) Tolerance Test, a New Quantitative Method for the Fibrin Stabilizing Factor (Factor XIII) Assay Authors Author Affiliations P Sigg 1 Coagulation Laboratory (Dr. F. Duckert) of the Department of Medicine (Head: Prof. Dr. F. Koller), University of Basle, Switzerland Recommend Article Abstract Buy Article(opens in new window) Summary A new quantitative test for the fibrin stabilizing factor (FSF, factor XIII) determination is described. The test is based on the principle of the reversible inhibition of the FSF action by monoiodoacetate (MIA). The definition of the MIA tolerance is given. The normal range is about 45. The MIA tolerance is studied under various conditions. No FSF free material is necessary for its performance. Full Text References References 1 Bachmann F, Duckert F, Koller F. The Stuart-Prower Factor Assay and its Clinical Significance. Thrombos. Diathes. haemorrh. (Stuttg) 02: 24 1958; 2 Beck E, Duckert F, Ernst M. The Influence of Fibrin Stabilizing Factor on the Growth of Fibroblasts in Vitro and Wound Healing. Thrombos. Diathes. haemorrh. (Stuttg) 06: 485 1961; 3 Glauss A. Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens. Acta haemat. (Basel) 17: 4 1957; 4 Duckert F, Jung E, Shmerling D. H. A Hitherto Undescribed Congenital Haemorrhagic Diathesis Probably Due to Fibrin Stabilizing Factor Deficiency. Thrombos. Diathes. haemorrh. (Stuttg) 05: 179 1960; 5 Duckert F. Le diagnostic des coagulopathies. Röntgenu. Lab.-Prax 13: 652 1960; 6 Duckert F, Flückiger P, Isenschmid H, Matter M, Vogel-Meng J, Koller F. A Modification of the Thromboplastin Generation Test. Acta haemat. (Basel) 12: 197 1954; 7 Geiger M, Duckert F, Koller F. Quantitative Bestimmungen von Factor VIII und IX bei Blutersippen. ö.Europ. Congr. Soc. Haemat. Springer; Heidelberg: 1956 8 Ikkala E, Nevanlinna H. R. Congenital Deficiency of Fibrin Stabilizing Factor. Thrombos. Diathes. haemorrh. (Stuttg) 07: 567 1962; 9 Josso F, Prou-Wartelle O, Alagille D, Soulier J. P. Le déficit congénital en facteur stabilisant de la fibrine (facteur XIII). Etudes sur deux cas. Nouv. Rév. franc. Hémat 04: 276 1964; 10 Rappeler R. Das Verhalten von Faktor V im Serum unter normalen und p Uhologischen Bedingungen. Z. klin. Med 153: 103 1955; 11 Koller F, Loeliger A, Duckert F. Experiments on a New Clotting Factor (Factor VII). Acta haemat. (Basel) 06: 1 1951; 12 Loki K, Lorand L. On the Solubility of Fibrin Clots. Science 108: 208 1948; 13 Loewy A. G, Edsall I. T. Studies on the Formation of Urea-insoluble Fibrin. J. biol. Chem 211: 289 1954; 14 Lüscher F. F. Ein fibrinstabilisierender Faktor aus Thrombozyten. Schweiz, med. Wschr 87: 1220 1957; 15 Mandelli F. Sindrome Emorragica da Diffetto del Fattore Stabilizante Fibrinico di Laki e Lorand. Med. clin. sper 13: 175 1963; 16 Masure R. Trouble congénital de l’hémostase associé à un déficit en Facteur Stabilisant de la Fibrine (F. S. F). Hémostase 03: 119 1963; 17 Müller G. Personal communication. 1964 18 Robbins K. C. A Study of the Conversion of Fibrinogen to Fibrin. Amer. J. Physiol 142: 581 1944; 19 Shmerling D. H, Jung E, Duckert F. Eine neue familiäre Koagulopathie infolge Mangels an fibrinstabilisierendem Factor. Helv. paediat. Acta 15: 471 1960; 20 Swigert S. t, Koppel J. L, Olwin J. H. Selective Inactivation of Fibrin Stabilizing Factor Contaminant in Fibrinogen. Nature (Lond) 198: 797 1963; 21 Sigg P. E, Duckert F. Ein neuer Test zur Bestimmung des fibrinstabilisierenden Faktors. Schweiz, med. Wschr 93: 1455 1963; 22 Zollinger W. Familienuntersuchung beim kongenitalen F aktor VII-Mangel. Klaus - Stiftung 28: 5 1963;
