On Intraocular Fibrinolysis^[*]

Summary

1. Intraocular fibrinolysis can be induced in rabbits by intravenous administration of streptokinase and plasminogen. Enhancement of intraocular fibrinolysis, however, requires a substantial increase in the fibrinolytic activity of the blood. Hence any attempt to induce therapeutic intraocular fibrinolysis by injection of fibrinolytic enzymes without checking the degree of fibrinolysis in the blood is meaningless.

2. The blood-aqueous barrier did not show any significant change during fibrinolytic activation.

3. Fibrinolytic split products could not be demonstrated in primary and plasmoid aqueous humour, but they were found in plasmoid aqueous after treatment of the animals with streptokinase and plasminogen.

4. Intraocular fibrinolysis can be inhibited in primary and plasmoid aqueous by parenteral administration of ε-ACA.

^* This investigation was supported by grants from the Swedish Medical Research Council and from the National Institutes of Health, Public Health Service (Research Grant HE-07066).

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