On Intraocular Fibrinolysis

M Pandolfi; Inga Marie Nilsson; J. E Niléhn

doi:10.1055/s-0038-1649419

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1966; 15(01/02): 161-172
DOI: 10.1055/s-0038-1649419

Originalarbeiten — Original Articles — Travaux Originaux

Schattauer GmbH

On Intraocular Fibrinolysis^[*]

M Pandolfi

¹Coagulation Laboratory, Department of Medicine, University of Lund, Allmänna Sjukhuset, Malmö, Sweden

,

Inga Marie Nilsson

¹Coagulation Laboratory, Department of Medicine, University of Lund, Allmänna Sjukhuset, Malmö, Sweden

,

J. E Niléhn

¹Coagulation Laboratory, Department of Medicine, University of Lund, Allmänna Sjukhuset, Malmö, Sweden

› Author Affiliations

Abstract

Summary

1. Intraocular fibrinolysis can be induced in rabbits by intravenous administration of streptokinase and plasminogen. Enhancement of intraocular fibrinolysis, however, requires a substantial increase in the fibrinolytic activity of the blood. Hence any attempt to induce therapeutic intraocular fibrinolysis by injection of fibrinolytic enzymes without checking the degree of fibrinolysis in the blood is meaningless.

2. The blood-aqueous barrier did not show any significant change during fibrinolytic activation.

3. Fibrinolytic split products could not be demonstrated in primary and plasmoid aqueous humour, but they were found in plasmoid aqueous after treatment of the animals with streptokinase and plasminogen.

4. Intraocular fibrinolysis can be inhibited in primary and plasmoid aqueous by parenteral administration of ε-ACA.

Full Text

References

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On Intraocular Fibrinolysis[*]

On Intraocular Fibrinolysis^[*]